4KEJ
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R169Q
Summary for 4KEJ
Entry DOI | 10.2210/pdb4kej/pdb |
Related | 3IM5 3IM6 3IM7 3QR5 4KEI 4KEK |
Descriptor | Ryanodine receptor 2 (2 entities in total) |
Functional Keywords | ca2+ release, ion channel, er/sr membrane, metal transport |
Biological source | Mus musculus (mouse) |
Cellular location | Sarcoplasmic reticulum membrane; Multi-pass membrane protein (Probable): E9Q401 |
Total number of polymer chains | 1 |
Total formula weight | 24138.14 |
Authors | Kimlicka, L.,Van Petegem, F. (deposition date: 2013-04-25, release date: 2013-09-04, Last modification date: 2023-09-20) |
Primary citation | Amador, F.J.,Kimlicka, L.,Stathopulos, P.B.,Gasmi-Seabrook, G.M.,Maclennan, D.H.,Van Petegem, F.,Ikura, M. Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy. J.Mol.Biol., 425:4034-4046, 2013 Cited by PubMed: 23978697DOI: 10.1016/j.jmb.2013.08.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.553 Å) |
Structure validation
Download full validation report