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PDB: 21 results
4FDD
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BU of 4fdd by Molmil
Crystal structure of KAP beta2-PY-NLS
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Zhang, Z.C, Chook, Y.M.
Deposit date:2012-05-28
Release date:2012-07-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Proc.Natl.Acad.Sci.USA, 109, 2012
2Z5K
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BU of 2z5k by Molmil
Complex of Transportin 1 with TAP NLS
Descriptor: Nuclear RNA export factor 1, PHOSPHATE ION, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Kose, S, Imamoto, N, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
4OO6
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BU of 4oo6 by Molmil
Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
Descriptor: RNA-binding protein 39, Transportin-1
Authors:Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2014-01-30
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
7CYL
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BU of 7cyl by Molmil
Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Chook, Y.M.
Deposit date:2020-09-03
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Sci Rep, 11, 2021
5YVI
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BU of 5yvi by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
1QBK
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BU of 1qbk by Molmil
STRUCTURE OF THE KARYOPHERIN BETA2-RAN GPPNHP NUCLEAR TRANSPORT COMPLEX
Descriptor: KARYOPHERIN BETA2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Chook, Y.M, Blobel, G.
Deposit date:1999-04-23
Release date:1999-06-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
Nature, 399, 1999
4FQ3
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BU of 4fq3 by Molmil
Crystal structure of transportin/FUS-NLS
Descriptor: Fusion (Involved in t(12;16) in malignant liposarcoma), Transportin-1
Authors:Gong, W, Niu, C, Jia, M, Gao, F.
Deposit date:2012-06-25
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of transportin/FUS-NLS
To be Published
5TQC
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BU of 5tqc by Molmil
Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of ribosomal protein L4 (RpL4)
Descriptor: 60S ribosomal protein L4-like protein, Transportin-1,Transportin-1
Authors:Huber, F.M, Hoelz, A.
Deposit date:2016-10-23
Release date:2017-02-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for protection of ribosomal protein L4 from cellular degradation.
Nat Commun, 8, 2017
2QMR
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BU of 2qmr by Molmil
Karyopherin beta2/transportin
Descriptor: Transportin-1
Authors:Cansizoglu, A.E, Chook, Y.M.
Deposit date:2007-07-16
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Conformational heterogeneity of karyopherin beta2 is segmental
Structure, 15, 2007
2Z5M
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BU of 2z5m by Molmil
Complex of Transportin 1 with TAP NLS, crystal form 2
Descriptor: Nuclear RNA export factor 1, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
5J3V
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BU of 5j3v by Molmil
Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail
Descriptor: Histone H3, Transportin-1,Transportin-1
Authors:Soniat, M, Chook, Y.M.
Deposit date:2016-03-31
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Karyopherin-beta 2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.
Structure, 24, 2016
4JLQ
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BU of 4jlq by Molmil
Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2
Descriptor: Nuclear polyadenylated RNA-binding protein NAB2, Transportin-1
Authors:Sampathkumar, P, Gizzi, A, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2013-03-12
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
J.Struct.Funct.Genom., 14, 2013
2H4M
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BU of 2h4m by Molmil
Karyopherin Beta2/Transportin-M9NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein A1, Transportin-1
Authors:Chook, Y.M, Cansizoglu, A.E.
Deposit date:2006-05-24
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
2OT8
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BU of 2ot8 by Molmil
Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Descriptor: Heterogeneous nuclear ribonucleoprotein M, Transportin-1
Authors:Cansizoglu, A.E, Chook, Y.M.
Deposit date:2007-02-07
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007
5YVH
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BU of 5yvh by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(371-526)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
8SGH
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BU of 8sgh by Molmil
Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1
Authors:Gonzalez, A, Fung, H.Y.J, Chook, Y.M.
Deposit date:2023-04-12
Release date:2023-06-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Structure, 31, 2023
2Z5N
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BU of 2z5n by Molmil
Complex of Transportin 1 with hnRNP D NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D0, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5O
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BU of 2z5o by Molmil
Complex of Transportin 1 with JKTBP NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D-like, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5J
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BU of 2z5j by Molmil
Free Transportin 1
Descriptor: Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
Deposit date:2007-07-13
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
7VPW
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BU of 7vpw by Molmil
Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724)
Descriptor: BRCA1-associated protein 1 (BAP1), Transportin-1
Authors:Yang, T.J, Hsu, S.T.D.
Deposit date:2021-10-18
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.76 Å)
Cite:Tumor suppressor BAP1 nuclear import is governed by transportin-1.
J.Cell Biol., 221, 2022
5YVG
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BU of 5yvg by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(full length)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.05 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018

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