6E7R
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6E7U
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6E7T
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6E7X
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3QEL
| Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | Deposit date: | 2011-01-20 | Release date: | 2011-06-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature, 475, 2011
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6E7V
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6E7W
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6E7S
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3JPW
| Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | Deposit date: | 2009-09-04 | Release date: | 2009-12-08 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Embo J., 28, 2009
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8G18
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5B3J
| Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | Descriptor: | Fab, heavy chain, light chain, ... | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | Deposit date: | 2016-03-01 | Release date: | 2016-05-11 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil Nature, 534, 2016
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7SAA
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3QEM
| Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | Deposit date: | 2011-01-20 | Release date: | 2011-06-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature, 475, 2011
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5TPZ
| Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ... | Authors: | Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H. | Deposit date: | 2016-10-21 | Release date: | 2016-12-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.095 Å) | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron, 92, 2016
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3JPY
| Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | Deposit date: | 2009-09-04 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.209 Å) | Cite: | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Embo J., 28, 2009
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6WI1
| GluN1b-GluN2B NMDA receptor in active conformation stabilized by inter-GluN1b-GluN2B subunit cross-linking | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ionotropic glutamate receptor , ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-07-15 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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7SAC
| S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution | Descriptor: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7TE9
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6WHU
| GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 1 | Descriptor: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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4PE5
| Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | Authors: | Karakas, E, Furukawa, H. | Deposit date: | 2014-04-22 | Release date: | 2014-06-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.96 Å) | Cite: | Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
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7SAD
| Memantine-bound GluN1a-GluN2B NMDA receptors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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6WHR
| GluN1b-GluN2B NMDA receptor in non-active 2 conformation at 4 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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6WHS
| GluN1b-GluN2B NMDA receptor in non-active 1 conformation at 3.95 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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6WHY
| GluN1b-GluN2B NMDA receptor in complex with GluN1 antagonist L689,560, class 1 | Descriptor: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-07-15 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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6WHV
| GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 2 | Descriptor: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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