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PDB: 167 results
9MF3
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BU of 9mf3 by Molmil
Crystal Structure of macrophage migration inhibitory factor from Plasmodium knowlesi
Descriptor: CHLORIDE ION, ISOPROPYL ALCOHOL, L-dopachrome isomerase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-12-09
Release date:2024-12-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of macrophage migration inhibitory factor from Plasmodium knowlesi
To be published
4DH4
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BU of 4dh4 by Molmil
Macrophage migration inhibitory factor Toxoplasma gondii
Descriptor: MIF, SULFATE ION
Authors:Richardson, J.M.
Deposit date:2012-01-27
Release date:2012-11-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor.
J.Biol.Chem., 288, 2013
3JSF
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BU of 3jsf by Molmil
Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution
Descriptor: 7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION
Authors:Mclean, L, Zhang, Y.
Deposit date:2009-09-10
Release date:2009-11-10
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19, 2009
1UIZ
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BU of 1uiz by Molmil
Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.
Descriptor: Macrophage Migration Inhibitory Factor
Authors:Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T.
Deposit date:2003-07-24
Release date:2004-05-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development.
J.Biol.Chem., 279, 2004
5J7Q
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BU of 5j7q by Molmil
Macrophage Migration Inhibitory Factor bound to Inhibitor K664 Derivative
Descriptor: 4-(imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diol, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Robertson, M.J, Jorgensen, W.L.
Deposit date:2016-04-06
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.
Bioorg.Med.Chem.Lett., 26, 2016
8IMR
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BU of 8imr by Molmil
Structure of ligand-free human macrophage migration inhibitory factor
Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
Deposit date:2023-03-07
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
8AP3
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BU of 8ap3 by Molmil
Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
Descriptor: MIF homologue
Authors:Manjula, R, Basquin, J, Lolis, E.
Deposit date:2022-08-09
Release date:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
To Be Published
1LJT
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BU of 1ljt by Molmil
Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)
Descriptor: 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER, Macrophage migration inhibitory factor
Authors:Lubetsky, J.B, Dios, A, Han, J, Aljabari, B, Ruzsicska, B, Mitchell, R, Lolis, E, Al-Abed, Y.
Deposit date:2002-04-22
Release date:2002-11-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents
J.Biol.Chem., 277, 2002
5XEJ
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BU of 5xej by Molmil
Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX
Descriptor: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION
Authors:Takimoto-Kamimura, M, Fukushima, K.
Deposit date:2017-04-05
Release date:2018-07-25
Last modified:2025-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of macrophage migration inhibitory factor in complex with methotrexate.
Acta Crystallogr D Struct Biol, 77, 2021
5J7P
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Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785
Descriptor: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Robertson, M.J, Jorgensen, W.L.
Deposit date:2016-04-06
Release date:2016-05-04
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.
Bioorg.Med.Chem.Lett., 26, 2016
6ICE
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BU of 6ice by Molmil
Crystal structure of Hamster MIF
Descriptor: Macrophage migration inhibitory factor
Authors:Sundaram, R, Vasudevan, D.
Deposit date:2018-09-05
Release date:2019-09-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer.
Sci Rep, 9, 2019
7KQX
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BU of 7kqx by Molmil
MIF Y99C homotrimeric mutant
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Manjula, R, Georgios, P, Lolis, E.J.
Deposit date:2020-11-18
Release date:2022-01-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
Front Mol Biosci, 9, 2022
2GDG
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BU of 2gdg by Molmil
Crystal structure of covalently modified macrophage inhibitory factor
Descriptor: Macrophage migration inhibitory factor
Authors:Golubkov, P.A, Hackert, M.L.
Deposit date:2006-03-16
Release date:2006-07-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Bioorg.Chem., 34, 2006
3SMC
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BU of 3smc by Molmil
Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound L-sulforaphane
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N-{4-[(R)-methylsulfinyl]butyl}thioformamide, ...
Authors:Crichlow, G.V, Lolis, E.J.
Deposit date:2011-06-27
Release date:2012-10-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.
Biochemistry, 51, 2012
3SMB
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BU of 3smb by Molmil
Phenethylisothiocyanate Covalently Bound to Macrophage Migration Inhibitory Factor (MIF)
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ...
Authors:Crichlow, G.V, Lolis, E.J.
Deposit date:2011-06-27
Release date:2012-10-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.
Biochemistry, 51, 2012
7XTX
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BU of 7xtx by Molmil
High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
4XX7
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BU of 4xx7 by Molmil
Crystal structure of M2A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-01-29
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
4XX8
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BU of 4xx8 by Molmil
Crystal structure of Pro1 deletion mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-01-30
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
7XVX
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BU of 7xvx by Molmil
Neutron crystal structure of human macrophage migration inhibitory factor
Descriptor: Macrophage migration inhibitory factor
Authors:Ezawa, T, Tamada, T, Odaka, M, Matsumura, H.
Deposit date:2022-05-25
Release date:2023-05-31
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION
Cite:Neutron crystal structure of human macrophage migration inhibitory factor
To Be Published
4WRB
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190)
Descriptor: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
Deposit date:2014-10-23
Release date:2015-03-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
6FVE
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BU of 6fve by Molmil
Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound FITC
Descriptor: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(E)-(sulfanylmethylidene)amino]benzoic acid, Macrophage migration inhibitory factor, SULFATE ION
Authors:Samygina, V.R, Bourenkov, G, Sokolov, A.V.
Deposit date:2018-03-02
Release date:2018-06-06
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
4WR8
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)
Descriptor: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ...
Authors:Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
Deposit date:2014-10-23
Release date:2015-03-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
1HFO
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BU of 1hfo by Molmil
The Structure of the Macrophage Migration Inhibitory Factor from Trichinella Spiralis.
Descriptor: MIGRATION INHIBITORY FACTOR
Authors:Roe, S.M, Meyer, D.J.
Deposit date:2000-12-07
Release date:2001-08-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Macrophage Migration Inhibitory Factor of the Parasitic Nematode Trichinella Spiralis
Biochem.J., 357, 2001
8DQ6
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BU of 8dq6 by Molmil
Structure of A. thaliana MIF/D-DT-like protein-1 (MDL1)
Descriptor: CALCIUM ION, MIF/D-DT-like protein-1
Authors:Manjula, R, Basquin, J, Lolis, E.
Deposit date:2022-07-18
Release date:2023-07-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.
Sci.Signal., 16, 2023
8DQA
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BU of 8dqa by Molmil
Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)
Descriptor: LS1-like protein
Authors:Manjula, R, Basquin, J, Lolis, E.
Deposit date:2022-07-18
Release date:2023-07-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.
Sci.Signal., 16, 2023

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