1LJT
Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)
Summary for 1LJT
Entry DOI | 10.2210/pdb1ljt/pdb |
Descriptor | Macrophage migration inhibitory factor, 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | protein-inhibitor complex, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P14174 |
Total number of polymer chains | 3 |
Total formula weight | 37770.88 |
Authors | Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y. (deposition date: 2002-04-22, release date: 2002-11-27, Last modification date: 2024-02-14) |
Primary citation | Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y. The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents J.Biol.Chem., 277:24976-24982, 2002 Cited by PubMed: 11997397DOI: 10.1074/jbc.M203220200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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