1ZP2
 
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1BU2
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9CB3
 | | E2F1-Cyclin F Interface | | Descriptor: | Cyclin-F, E2F1 peptide, S-phase kinase-associated protein 1 | | Authors: | Ngoi, P, Serrao, V.H, Rubin, S.M. | | Deposit date: | 2024-06-18 | | Release date: | 2025-02-12 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F.
Proc.Natl.Acad.Sci.USA, 122, 2025
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1VIN
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1JKW
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1KXU
 | | CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE | | Descriptor: | CYCLIN H | | Authors: | Kim, K.K, Chamberin, H.M, Morgan, D.O, Kim, S.-H. | | Deposit date: | 1996-08-08 | | Release date: | 1997-01-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Nat.Struct.Biol., 3, 1996
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2PK2
 | | Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat | | Descriptor: | Cyclin-T1, Protein Tat | | Authors: | Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. | | Deposit date: | 2007-04-17 | | Release date: | 2007-07-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
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7LUO
 | | N-terminus of Skp2 bound to Cyclin A | | Descriptor: | S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2 | | Authors: | Kelso, S, Ceccarelli, D.F, Sicheri, F. | | Deposit date: | 2021-02-22 | | Release date: | 2021-05-12 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | Bipartite binding of the N terminus of Skp2 to cyclin A.
Structure, 29, 2021
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2I53
 | | Crystal structure of Cyclin K | | Descriptor: | ACETATE ION, Cyclin K | | Authors: | Baek, K, Brown, R.S, Birrane, G, Ladias, J.A.A. | | Deposit date: | 2006-08-23 | | Release date: | 2007-01-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
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2IVX
 | | Crystal structure of human cyclin T2 at 1.8 A resolution | | Descriptor: | 1,2-ETHANEDIOL, CYCLIN-T2 | | Authors: | Debreczeni, J.E, Bullock, A.N, Fedorov, O, Savitsky, P, Berridge, G, Das, S, Pike, A.C.W, Turnbull, A, Ugochukwu, E, Papagrigoriou, E, Gorrec, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. | | Deposit date: | 2006-06-21 | | Release date: | 2006-07-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
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6Q6H
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6Q6G
 | | Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class | | Descriptor: | Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Zhang, S, Barford, D. | | Deposit date: | 2018-12-11 | | Release date: | 2019-09-11 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Nat Commun, 10, 2019
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2B9R
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9IVD
 | | Cryo-EM structure of CyclinD1 bound AMBRA1-DDB1 | | Descriptor: | Activating molecule in BECN1-regulated autophagy protein 1, DNA damage-binding protein 1, G1/S-specific cyclin-D1 | | Authors: | Wang, Y, Liu, M, Su, M.-Y, Stjepanovic, G. | | Deposit date: | 2024-07-23 | | Release date: | 2025-04-23 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor.
Sci Adv, 11, 2025
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2W2H
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7NJ0
 | | CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex | | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ... | | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | | Deposit date: | 2021-02-14 | | Release date: | 2021-08-04 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
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1E9H
 | | Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound | | Descriptor: | 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A3 | | Authors: | Davies, T.G, Tunnah, P, Noble, M.E.M, Endicott, J.A. | | Deposit date: | 2000-10-16 | | Release date: | 2001-10-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Structure, 9, 2001
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7XQK
 | | The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus. | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, G1/S-specific cyclin-E1, GLYCEROL, ... | | Authors: | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y. | | Deposit date: | 2022-05-07 | | Release date: | 2023-05-17 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural basis of CDK3 activation by cyclin E1 and inhibition by dinaciclib.
Biochem.Biophys.Res.Commun., 662, 2023
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1QMZ
 | | PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, ... | | Authors: | Brown, N.R, Noble, M.E.M, Endicott, J.A, Johnson, L.N. | | Deposit date: | 1999-10-11 | | Release date: | 1999-12-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases
Nat.Cell Biol., 1, 1999
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6XD3
 | | Structure of the human CAK in complex with THZ1 | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | | Deposit date: | 2020-06-09 | | Release date: | 2020-09-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The cryoelectron microscopy structure of the human CDK-activating kinase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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9JK1
 | | Crystal structure of CDK12/Cyclin K in complex with covalent inhibitor YJZ5118 | | Descriptor: | 1,2-ETHANEDIOL, Cyclin-K, Cyclin-dependent kinase 12, ... | | Authors: | Huang, W.X, Zhang, P.J, Yang, J.Z, Ding, K. | | Deposit date: | 2024-09-14 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Discovery of YJZ5118 : A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition.
J.Med.Chem., 68, 2025
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4UN0
 | | Crystal structure of the human CDK12-cyclinK complex | | Descriptor: | CYCLIN-DEPENDENT KINASE 12, CYCLIN-K | | Authors: | Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Chaikuad, A, Goubin, S, Krojer, T, Sorrell, F.J, Nowak, R, Williams, E, Kopec, J, Mahajan, R.P, Burgess-Brown, N, Carpenter, E.P, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | | Deposit date: | 2014-05-22 | | Release date: | 2014-06-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding.
Sci.Rep., 5, 2015
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5NEV
 | | CDK2/Cyclin A in complex with compound 73 | | Descriptor: | 4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E.M, Newell, D.R, Turner, D, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Cano, G. | | Deposit date: | 2017-03-12 | | Release date: | 2017-03-29 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
J. Med. Chem., 60, 2017
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2JGZ
 | | Crystal structure of phospho-CDK2 in complex with Cyclin B | | Descriptor: | CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1 | | Authors: | Brown, N.R, Petri, E, Lowe, E.D, Skamnaki, V, Johnson, L.N. | | Deposit date: | 2007-02-17 | | Release date: | 2007-05-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell Cycle, 6, 2007
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7SJ3
 | | Structure of CDK4-Cyclin D3 bound to abemaciclib | | Descriptor: | Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | | Authors: | Hilgers, M.T, Pelletier, L.A. | | Deposit date: | 2021-10-15 | | Release date: | 2022-11-02 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy.
NPJ Breast Cancer, 8, 2022
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