1BU2

X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI

Summary for 1BU2

Entry DOI	10.2210/pdb1bu2/pdb
Descriptor	CYCLIN HOMOLOG (1 entity in total)
Functional Keywords	cell cycle regulation, herpesvirus saimiri, viral cyclin
Biological source	Herpesvirus saimiri (strain 11)
Total number of polymer chains	1
Total formula weight	25849.15
Authors	Schulze-Gahmen, U.,Jung, J.U.,Kim, S.-H. (deposition date: 1998-09-10, release date: 1999-06-15, Last modification date: 2024-02-07)
Primary citation	Schulze-Gahmen, U.,Jung, J.U.,Kim, S.H. Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6. Structure Fold.Des., 7:245-254, 1999 Cited by PubMed Abstract: Cyclin-dependent kinases (CDKs) have a central role in cell-cycle control and are activated by complex formation with positive regulatory proteins called cyclins and by phosphorylation. The overexpression and mutation of cyclins and CDKs has been associated with tumorigenesis and oncogenesis. A virus-encoded cyclin (v-cyclin) from herpesvirus saimiri has been shown to exhibit highest sequence homology to type D cyclins and specifically activates CDK6 of host cells to a very high degree. PubMed: 10368294 DOI: 10.1016/S0969-2126(99)80035-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation