1N7S
 
 | | High Resolution Structure of a Truncated Neuronal SNARE Complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, SNAP-25A, ... | | Authors: | Ernst, J.A, Brunger, A.T. | | Deposit date: | 2002-11-16 | | Release date: | 2002-12-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | High Resolution Structure, Stability, and Synaptotagmin Binding of a Truncated Neuronal SNARE Complex
J.Biol.Chem., 278, 2003
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5W5C
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6WVW
 | | Crystal structure of the R59P-SNAP25 containing SNARE complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Synaptosomal-associated protein 25, ... | | Authors: | Zhou, Q, White, K.I, Brunger, A.T. | | Deposit date: | 2020-05-07 | | Release date: | 2021-03-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Neuron, 109, 2021
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1KIL
 | | Three-dimensional structure of the complexin/SNARE complex | | Descriptor: | Complexin I SNARE-complex binding region, MAGNESIUM ION, SNAP-25 C-terminal SNARE motif, ... | | Authors: | Chen, X, Tomchick, D, Kovrigin, E, Arac, D, Machius, M, Sudhof, T.C, Rizo, J. | | Deposit date: | 2001-12-03 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Three-dimensional structure of the complexin/SNARE complex.
Neuron, 33, 2002
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1SFC
 | | NEURONAL SYNAPTIC FUSION COMPLEX | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN (SNAP-25B), PROTEIN (SYNAPTOBREVIN 2), ... | | Authors: | Sutton, R.B, Brunger, A.T. | | Deposit date: | 1998-08-24 | | Release date: | 1998-10-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.
Nature, 395, 1998
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5W5D
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6A30
 | | Crystal Structure of Munc13-1 MUN Domain and Synaptobrevin-2 Juxtamembrane Linker Region | | Descriptor: | Protein unc-13 homolog A, Synaptobrevin-2 juxtamembrane linker peptide | | Authors: | Wang, S, Li, Y, Gong, J.H, Ye, S, Yang, X.F, Zhang, R.G, Ma, C. | | Deposit date: | 2018-06-14 | | Release date: | 2019-01-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.793 Å) | | Cite: | Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.
Nat Commun, 10, 2019
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3HD7
 | | HELICAL EXTENSION OF THE NEURONAL SNARE COMPLEX INTO THE MEMBRANE, spacegroup C 1 2 1 | | Descriptor: | SULFATE ION, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Stein, A, Weber, G, Wahl, M.C, Jahn, R. | | Deposit date: | 2009-05-07 | | Release date: | 2009-07-14 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Helical extension of the neuronal SNARE complex into the membrane
Nature, 460, 2009
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5CCG
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) | | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | Deposit date: | 2015-07-02 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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7UDB
 | | Cryo-EM structure of a synaptobrevin-Munc18-1-syntaxin-1 complex class 2 | | Descriptor: | Synaptobrevin-2, Syntaxin-1A, Syntaxin-binding protein 1 | | Authors: | Rizo, J, Bai, X, Stepien, K.P, Xu, J, Zhang, X. | | Deposit date: | 2022-03-18 | | Release date: | 2022-04-06 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Sci Adv, 8, 2022
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5CCH
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | Deposit date: | 2015-07-02 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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6IP1
 | | alpha-SNAP-SNARE subcomplex in the whole 20S complex | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. | | Deposit date: | 2018-11-01 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanistic insights into the SNARE complex disassembly.
Sci Adv, 5, 2019
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5CCI
 | | Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | Descriptor: | MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Weis, W.I, Brunger, A.T. | | Deposit date: | 2015-07-02 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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6MDN
 | | The 20S supercomplex engaging the SNAP-25 N-terminus (class 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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6MDM
 | | The 20S supercomplex engaging the SNAP-25 N-terminus (class 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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3IPD
 | | Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21 | | Descriptor: | Synaptosomal-associated protein 25, Syntaxin-1A, Vesicle-associated membrane protein 2 | | Authors: | Stein, A, Weber, G, Wahl, M.C, Jahn, R. | | Deposit date: | 2009-08-17 | | Release date: | 2009-09-01 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (4.8 Å) | | Cite: | Helical extension of the neuronal SNARE complex into the membrane
Nature, 460, 2009
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3J96
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State I) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J97
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State II) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J99
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIb) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J98
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIa) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (8.4 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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6MTI
 | | Synaptotagmin-1 C2A, C2B domains and SNARE-pin proteins (5CCI) individually docked into Cryo-EM map of C2AB-SNARE complexes helically organized on lipid nanotube surface in presence of Mg2+ | | Descriptor: | MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | Authors: | Grushin, K, Wang, J, Coleman, J, Rothman, J, Sindelar, C, Krishnakumar, S. | | Deposit date: | 2018-10-19 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (10.4 Å) | | Cite: | Structural basis for the clamping and Ca2+activation of SNARE-mediated fusion by synaptotagmin.
Nat Commun, 10, 2019
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2N1T
 | | Dynamic binding mode of a synaptotagmin-1-SNARE complex in solution | | Descriptor: | Synaptosomal-associated protein 25, Synaptotagmin-1, Syntaxin-1A, ... | | Authors: | Brewer, K, Bacaj, T, Cavalli, A, Camilloni, C, Swarbrick, J, Liu, J, Zhou, A, Zhou, P, Barlow, N, Xu, J, Seven, A, Prinslow, E, Voleti, R, Haussinger, D, Bonvin, A, Tomchick, D, Vendruscolo, M, Graham, B, Sudhof, T, Rizo, J. | | Deposit date: | 2015-04-21 | | Release date: | 2015-06-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.
Nat.Struct.Mol.Biol., 22, 2015
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2KOG
 | | lipid-bound synaptobrevin solution NMR structure | | Descriptor: | Vesicle-associated membrane protein 2 | | Authors: | Ellena, J.F, Liang, B, Wiktor, M, Stein, A, Cafiso, D.S, Jahn, R, Tamm, L.K. | | Deposit date: | 2009-09-22 | | Release date: | 2009-12-01 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation.
Proc.Natl.Acad.Sci.USA, 106, 2009
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