1N7S
High Resolution Structure of a Truncated Neuronal SNARE Complex
Summary for 1N7S
| Entry DOI | 10.2210/pdb1n7s/pdb |
| Descriptor | vesicle-associated membrane protein 2, Syntaxin 1A, SNAP-25A, ... (7 entities in total) |
| Functional Keywords | neuronal snare protein complex, four helix bundle, transport protein |
| Biological source | Rattus norvegicus (Norway rat) More |
| Cellular location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein: P63045 P32851 Cytoplasm, perinuclear region : P60881 P60881 |
| Total number of polymer chains | 4 |
| Total formula weight | 32097.08 |
| Authors | Ernst, J.A.,Brunger, A.T. (deposition date: 2002-11-16, release date: 2002-12-27, Last modification date: 2024-02-14) |
| Primary citation | Ernst, J.A.,Brunger, A.T. High Resolution Structure, Stability, and Synaptotagmin Binding of a Truncated Neuronal SNARE Complex J.Biol.Chem., 278:8630-8636, 2003 Cited by PubMed Abstract: The structure of a truncated SNARE complex has been solved to 1.4-A resolution revealing a stabilizing salt bridge, sites of hydration, and conformational variability of the ionic central layer that were not observed in a previously published structure at 2.4-A resolution (Sutton, R. B., Fasshauer, D., Jahn, R., and Brunger, A. T. (1998) Nature 395, 347-353). The truncated complex lacks residues involved in phospholipid binding and denatures at a lower temperature than longer complexes as assessed by SDS and circular dichroism thermal melts. The truncated SNARE complex is monomeric, and it retains binding to synaptotagmin I. PubMed: 12496247DOI: 10.1074/jbc.M211889200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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