3UB2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ub2 by Molmil](/molmil-images/mine/3ub2) | TIR domain of Mal/TIRAP | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Shen, Y, Lin, Z. | Deposit date: | 2011-10-23 | Release date: | 2012-05-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One, 7, 2012
|
|
4LQD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4lqd by Molmil](/molmil-images/mine/4lqd) | The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry | Descriptor: | GLYCEROL, Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Snyder, G.A, Smith, P, Jiang, J, Xiao, T.S. | Deposit date: | 2013-07-17 | Release date: | 2013-12-04 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (2.451 Å) | Cite: | Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289, 2014
|
|
3UB3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ub3 by Molmil](/molmil-images/mine/3ub3) | D96N variant of TIR domain of Mal/TIRAP | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Shen, Y, Lin, Z. | Deposit date: | 2011-10-23 | Release date: | 2012-05-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One, 7, 2012
|
|
2Y92
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y92 by Molmil](/molmil-images/mine/2y92) | Crystal structure of MAL adaptor protein | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN, | Authors: | Valkov, E, Stamp, A, Martin, J.L, Kobe, B. | Deposit date: | 2011-02-11 | Release date: | 2011-09-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3UB4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ub4 by Molmil](/molmil-images/mine/3ub4) | S180L variant of TIR domain of Mal/TIRAP | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Shen, Y, Lin, Z. | Deposit date: | 2011-10-23 | Release date: | 2012-05-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One, 7, 2012
|
|
4FZ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4fz5 by Molmil](/molmil-images/mine/4fz5) | Crystal Structure of Human TIRAP TIR-domain | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Woo, J.R, Kim, S, Shoelson, S.E, Park, S. | Deposit date: | 2012-07-06 | Release date: | 2013-05-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL) Bull.Korean Chem.Soc., 33, 2013
|
|
5UZB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5uzb by Molmil](/molmil-images/mine/5uzb) | Cryo-EM structure of the MAL TIR domain filament | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Ve, T, Vajjhala, P.R, Hedger, A, Croll, T, DiMaio, F, Horsefield, S, Yu, X, Lavrencic, P, Hassan, Z, Morgan, G.P, Mansell, A, Mobli, M, O'Carrol, A, Chauvin, B, Gambin, Y, Sierecki, E, Landsberg, M.J, Stacey, K.J, Egelman, E.H, Kobe, B. | Deposit date: | 2017-02-25 | Release date: | 2017-07-26 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nat. Struct. Mol. Biol., 24, 2017
|
|
8JZM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jzm by Molmil](/molmil-images/mine/8jzm) | The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210 | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B. | Deposit date: | 2023-07-05 | Release date: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. J Enzyme Inhib Med Chem, 39, 2024
|
|
5T7Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5t7q by Molmil](/molmil-images/mine/5t7q) | TIRAP phosphoinositide-binding motif | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Capelluto, D.G.S, Ellena, J.F, Armstrong, G, Zhao, X, Xiao, S. | Deposit date: | 2016-09-05 | Release date: | 2017-03-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif. Sci Rep, 7, 2017
|
|
2NDH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ndh by Molmil](/molmil-images/mine/2ndh) | NMR solution structure of MAL/TIRAP TIR domain (C116A) | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Lavrencic, P, Mobli, M. | Deposit date: | 2016-05-27 | Release date: | 2017-05-31 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|