5UZB
Cryo-EM structure of the MAL TIR domain filament
Summary for 5UZB
Entry DOI | 10.2210/pdb5uzb/pdb |
EMDB information | 8625 |
Descriptor | Toll/interleukin-1 receptor domain-containing adapter protein (1 entity in total) |
Functional Keywords | tir domain, adaptor proteins, tlr signaling, homotypic protein interactions, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 14 |
Total formula weight | 275648.27 |
Authors | Ve, T.,Vajjhala, P.R.,Hedger, A.,Croll, T.,DiMaio, F.,Horsefield, S.,Yu, X.,Lavrencic, P.,Hassan, Z.,Morgan, G.P.,Mansell, A.,Mobli, M.,O'Carrol, A.,Chauvin, B.,Gambin, Y.,Sierecki, E.,Landsberg, M.J.,Stacey, K.J.,Egelman, E.H.,Kobe, B. (deposition date: 2017-02-25, release date: 2017-07-26, Last modification date: 2020-01-15) |
Primary citation | Ve, T.,Vajjhala, P.R.,Hedger, A.,Croll, T.,DiMaio, F.,Horsefield, S.,Yu, X.,Lavrencic, P.,Hassan, Z.,Morgan, G.P.,Mansell, A.,Mobli, M.,O'Carroll, A.,Chauvin, B.,Gambin, Y.,Sierecki, E.,Landsberg, M.J.,Stacey, K.J.,Egelman, E.H.,Kobe, B. Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nat. Struct. Mol. Biol., 24:743-751, 2017 Cited by PubMed: 28759049DOI: 10.1038/nsmb.3444 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (7 Å) |
Structure validation
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