5UZB

Cryo-EM structure of the MAL TIR domain filament

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Toll/interleukin-1 receptor domain-containing adapter protein	polymer	177	19689.2	14	UniProt (P58753) Pfam (PF13676)	Homo sapiens (Human)	TIR domain-containing adapter protein,Adaptor protein Wyatt,MyD88 adapter-like protein,MyD88-2

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N: 79 - 221 (UniProt: P58753)

PDB	External Database	Details
Met 45	-	expression tag
His 46	-	expression tag
His 47	-	expression tag
His 48	-	expression tag
His 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
Ser 52	-	expression tag
Ser 53	-	expression tag
Gly 54	-	expression tag
Val 55	-	expression tag
Asp 56	-	expression tag
Leu 57	-	expression tag
Gly 58	-	expression tag
Thr 59	-	expression tag
Glu 60	-	expression tag
Asn 61	-	expression tag
Leu 62	-	expression tag
Tyr 63	-	expression tag
Phe 64	-	expression tag
Gln 65	-	expression tag
Ser 66	-	expression tag
Asn 67	-	expression tag
Ala 68	-	expression tag
Glu 69	-	expression tag
Gln 70	-	expression tag
Lys 71	-	expression tag
Leu 72	-	expression tag
Ile 73	-	expression tag
Ser 74	-	expression tag
Glu 75	-	expression tag
Glu 76	-	expression tag
Asp 77	-	expression tag
Leu 78	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	275648.3
All*	Total formula weight	275648.3

*Water molecules are not included.