4RAV
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![BU of 4rav by Molmil](/molmil-images/mine/4rav) | Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin | Descriptor: | Huntingtin, SULFATE ION, Single-chain Fv, ... | Authors: | De Genst, E, Chirgadze, D.Y, Dobson, C.M. | Deposit date: | 2014-09-11 | Release date: | 2015-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression. J.Mol.Biol., 427, 2015
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8VLX
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![BU of 8vlx by Molmil](/molmil-images/mine/8vlx) | HTT in complex with HAP40 and a small molecule. | Descriptor: | 40-kDa huntingtin-associated protein, Huntingtin, N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea | Authors: | Poweleit, N, Boudet, J, Doherty, E. | Deposit date: | 2024-01-12 | Release date: | 2024-03-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex To Be Published
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3LRH
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![BU of 3lrh by Molmil](/molmil-images/mine/3lrh) | |
6X9O
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![BU of 6x9o by Molmil](/molmil-images/mine/6x9o) | High resolution cryoEM structure of huntingtin in complex with HAP40 | Descriptor: | 40-kDa huntingtin-associated protein, Huntingtin | Authors: | Harding, R.J, Deme, J.C, Lea, S.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2020-06-03 | Release date: | 2020-06-17 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Commun Biol, 4, 2021
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8W15
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![BU of 8w15 by Molmil](/molmil-images/mine/8w15) | |
4FEB
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![BU of 4feb by Molmil](/molmil-images/mine/4feb) | Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta) | Descriptor: | Maltose-binding periplasmic protein,Huntingtin, SODIUM ION, ZINC ION | Authors: | Kim, M. | Deposit date: | 2012-05-29 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues. Prion, 7, 2013
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4FED
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![BU of 4fed by Molmil](/molmil-images/mine/4fed) | Crystal Structure of Htt36Q3H | Descriptor: | CALCIUM ION, Maltose-binding periplasmic protein,Huntingtin, ZINC ION | Authors: | Kim, M. | Deposit date: | 2012-05-30 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.807 Å) | Cite: | Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues. Prion, 7, 2013
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4FE8
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![BU of 4fe8 by Molmil](/molmil-images/mine/4fe8) | Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha) | Descriptor: | Maltose-binding periplasmic protein,Huntingtin, ZINC ION | Authors: | Kim, M. | Deposit date: | 2012-05-29 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues. Prion, 7, 2013
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4FEC
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![BU of 4fec by Molmil](/molmil-images/mine/4fec) | Crystal Structure of Htt36Q3H | Descriptor: | Maltose-binding periplasmic protein,Huntingtin, ZINC ION | Authors: | Kim, M. | Deposit date: | 2012-05-30 | Release date: | 2013-03-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues. Prion, 7, 2013
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8SAH
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![BU of 8sah by Molmil](/molmil-images/mine/8sah) | Huntingtin C-HEAT domain in complex with HAP40 | Descriptor: | 40-kDa huntingtin-associated protein, Huntingtin | Authors: | Harding, R.J, Deme, J.C, Alteen, M.G, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) | Deposit date: | 2023-03-31 | Release date: | 2023-04-26 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40. Structure, 31, 2023
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3IOT
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![BU of 3iot by Molmil](/molmil-images/mine/3iot) | |
3IOW
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![BU of 3iow by Molmil](/molmil-images/mine/3iow) | |
7DXJ
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![BU of 7dxj by Molmil](/molmil-images/mine/7dxj) | |
3IOR
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![BU of 3ior by Molmil](/molmil-images/mine/3ior) | |
3IO4
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![BU of 3io4 by Molmil](/molmil-images/mine/3io4) | Huntingtin amino-terminal region with 17 Gln residues - Crystal C90 | Descriptor: | CALCIUM ION, Maltose-binding periplasmic protein,Huntingtin fusion protein, ZINC ION | Authors: | Kim, M.W, Chelliah, Y, Kim, S.W, Otwinowski, Z, Bezprozvanny, I. | Deposit date: | 2009-08-13 | Release date: | 2009-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.63 Å) | Cite: | Secondary structure of Huntingtin amino-terminal region. Structure, 17, 2009
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3IOV
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![BU of 3iov by Molmil](/molmil-images/mine/3iov) | |
3IO6
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![BU of 3io6 by Molmil](/molmil-images/mine/3io6) | Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a | Descriptor: | CALCIUM ION, Maltose-binding periplasmic protein, HUNTINGTIN FUSION PROTEIN, ... | Authors: | Kim, M.W, Chelliah, Y, Kim, S.W, Otwinowski, Z, Bezprozvanny, I. | Deposit date: | 2009-08-13 | Release date: | 2009-10-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Secondary structure of Huntingtin amino-terminal region. Structure, 17, 2009
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3IOU
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![BU of 3iou by Molmil](/molmil-images/mine/3iou) | |
6EZ8
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![BU of 6ez8 by Molmil](/molmil-images/mine/6ez8) | Human Huntingtin-HAP40 complex structure | Descriptor: | Factor VIII intron 22 protein, Huntingtin | Authors: | Guo, Q, Bin, H, Cheng, J, Pfeifer, G, Baumeister, W, Fernandez-Busnadiego, R, Kochanek, S. | Deposit date: | 2017-11-14 | Release date: | 2018-02-21 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The cryo-electron microscopy structure of huntingtin. Nature, 555, 2018
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7DXK
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![BU of 7dxk by Molmil](/molmil-images/mine/7dxk) | |
6RMH
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![BU of 6rmh by Molmil](/molmil-images/mine/6rmh) | The Rigid-body refined model of the normal Huntingtin. | Descriptor: | Huntingtin | Authors: | Jung, T, Tamo, G, Dal Perraro, M, Hebert, H, Song, J. | Deposit date: | 2019-05-06 | Release date: | 2020-06-03 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (9.6 Å) | Cite: | The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure, 28, 2020
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6YEJ
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![BU of 6yej by Molmil](/molmil-images/mine/6yej) | Cryo-EM structure of the Full-length disease type human Huntingtin | Descriptor: | Huntingtin | Authors: | Tame, G, Jung, T, Dal Perraro, M, Hebert, H, Song, J. | Deposit date: | 2020-03-24 | Release date: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (18.200001 Å) | Cite: | The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure, 28, 2020
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2LD2
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![BU of 2ld2 by Molmil](/molmil-images/mine/2ld2) | |
2LD0
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![BU of 2ld0 by Molmil](/molmil-images/mine/2ld0) | |
6N8C
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![BU of 6n8c by Molmil](/molmil-images/mine/6n8c) | Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR | Descriptor: | Huntingtin | Authors: | Schwieters, C.D, Kotler, S.A, Schmidt, T, Ceccon, A, Ghirlando, R, Libich, D.S, Clore, G.M. | Deposit date: | 2018-11-29 | Release date: | 2019-02-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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