6YEJ

Cryo-EM structure of the Full-length disease type human Huntingtin

Summary for 6YEJ

Entry DOI	10.2210/pdb6yej/pdb
EMDB information	10793 4937
Descriptor	Huntingtin (1 entity in total)
Functional Keywords	multivalent scaffold platform, protein binding, structural protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	355278.72
Authors	Tame, G.,Jung, T.,Dal Perraro, M.,Hebert, H.,Song, J. (deposition date: 2020-03-24, release date: 2020-12-16)
Primary citation	Jung, T.,Shin, B.,Tamo, G.,Kim, H.,Vijayvargia, R.,Leitner, A.,Marcaida, M.J.,Astorga-Wells, J.,Jung, R.,Aebersold, R.,Peraro, M.D.,Hebert, H.,Seong, I.S.,Song, J.J. The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure, 28:1035-1050.e8, 2020 Cited by PubMed: 32668197 DOI: 10.1016/j.str.2020.06.008 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (18.2 Å)

Structure validation