6YEJ

Cryo-EM structure of the Full-length disease type human Huntingtin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Huntingtin	polymer	3199	355278.7	1	UniProt (P42858) Pfam (PF20926) Pfam (PF20925) Pfam (PF20927) In PDB	Homo sapiens (Human)	Huntington disease protein,HD protein

Sequence modifications

A: 69 - 3193 (UniProt: P42858)

PDB	External Database	Details
Met -5	-	initiating methionine
Ala -4	-	expression tag
Thr -3	-	expression tag
Leu -2	-	expression tag
Glu -1	-	expression tag
Lys 0	-	expression tag
Leu 1	-	expression tag
Met 2	-	expression tag
Lys 3	-	expression tag
Ala 4	-	expression tag
Phe 5	-	expression tag
Glu 6	-	expression tag
Ser 7	-	expression tag
Leu 8	-	expression tag
Lys 9	-	expression tag
Ser 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Gln 13	-	expression tag
Gln 14	-	expression tag
Gln 15	-	expression tag
Gln 16	-	expression tag
Gln 17	-	expression tag
Gln 18	-	expression tag
Gln 19	-	expression tag
Gln 20	-	expression tag
Gln 21	-	expression tag
Gln 22	-	expression tag
Gln 23	-	expression tag
Gln 24	-	expression tag
Gln 25	-	expression tag
Gln 26	-	expression tag
Gln 27	-	expression tag
Gln 28	-	expression tag
Gln 29	-	expression tag
Gln 30	-	expression tag
Gln 31	-	expression tag
Gln 32	-	expression tag
Gln 33	-	expression tag
Gln 34	-	expression tag
Gln 35	-	expression tag
Gln 36	-	expression tag
Gln 37	-	expression tag
Gln 38	-	expression tag
Gln 39	-	expression tag
Gln 40	-	expression tag
Gln 41	-	expression tag
Gln 42	-	expression tag
Gln 43	-	expression tag
Gln 44	-	expression tag
Gln 45	-	expression tag
Gln 46	-	expression tag
Gln 47	-	expression tag
Gln 48	-	expression tag
Gln 49	-	expression tag
Gln 50	-	expression tag
Gln 51	-	expression tag
Gln 52	-	expression tag
Gln 53	-	expression tag
Gln 54	-	expression tag
Gln 55	-	expression tag
Gln 56	-	expression tag
Gln 57	-	expression tag
Gln 58	-	expression tag
Gln 59	-	expression tag
Gln 60	-	expression tag
Gln 61	-	expression tag
Gln 62	-	expression tag
Gln 63	-	expression tag
Gln 64	-	expression tag
Gln 65	-	expression tag
Gln 66	-	expression tag
Gln 67	-	expression tag
Gln 68	-	expression tag
Arg 1289	Lys 1238	conflict
His 2360	Tyr 2309	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	355278.7
All*	Total formula weight	355278.7

*Water molecules are not included.