6YEJ
Cryo-EM structure of the Full-length disease type human Huntingtin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000132 | biological_process | establishment of mitotic spindle orientation |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005522 | molecular_function | profilin binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005776 | cellular_component | autophagosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005814 | cellular_component | centriole |
| A | 0005829 | cellular_component | cytosol |
| A | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007030 | biological_process | Golgi organization |
| A | 0016234 | cellular_component | inclusion body |
| A | 0019900 | molecular_function | kinase binding |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031072 | molecular_function | heat shock protein binding |
| A | 0031587 | biological_process | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| A | 0031648 | biological_process | protein destabilization |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034452 | molecular_function | dynactin binding |
| A | 0042297 | biological_process | vocal learning |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043666 | biological_process | regulation of phosphoprotein phosphatase activity |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0045724 | biological_process | positive regulation of cilium assembly |
| A | 0047496 | biological_process | vesicle transport along microtubule |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0048487 | molecular_function | beta-tubulin binding |
| A | 0099111 | biological_process | microtubule-based transport |
| A | 0099523 | cellular_component | presynaptic cytosol |
| A | 0099524 | cellular_component | postsynaptic cytosol |
| A | 1901526 | biological_process | positive regulation of mitophagy |
| A | 1904504 | biological_process | positive regulation of lipophagy |
| A | 1905289 | biological_process | regulation of CAMKK-AMPK signaling cascade |
| A | 1905337 | biological_process | positive regulation of aggrephagy |
| A | 2000479 | biological_process | regulation of cAMP-dependent protein kinase activity |
| A | 2001237 | biological_process | negative regulation of extrinsic apoptotic signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:9535906 |
| Chain | Residue | Details |
| A | ASP562 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by caspase-3 => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP579 | |
| A | ASP638 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:29802276 |
| Chain | Residue | Details |
| A | ASP601 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase-6 => ECO:0000269|PubMed:10770929 |
| Chain | Residue | Details |
| A | ASP635 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21685499 |
| Chain | Residue | Details |
| A | LYS227 | |
| A | LYS285 | |
| A | LYS394 | |
| A | LYS493 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER462 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42859 |
| Chain | Residue | Details |
| A | SER468 | |
| A | SER470 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER483 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER691 | |
| A | SER694 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17611284 |
| Chain | Residue | Details |
| A | SER1230 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17611284, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1250 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER1921 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1925 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:24459296, ECO:0000269|PubMed:29802276 |
| Chain | Residue | Details |
| A | GLY602 |
