3FQN
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3FQR
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7AFW
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![BU of 7afw by Molmil](/molmil-images/mine/7afw) | Beta-Catenin in complex with compound 6 | Descriptor: | 3-[(2~{R})-4-methyl-5-oxidanylidene-2,3-dihydro-1,4-benzoxazepin-2-yl]benzenecarbonitrile, Catenin beta-1 | Authors: | Boettcher, J, Kessler, D. | Deposit date: | 2020-09-21 | Release date: | 2020-12-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.814 Å) | Cite: | Getting a Grip on the Undrugged: Targeting beta-Catenin with Fragment-Based Methods. Chemmedchem, 16, 2021
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1JDH
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![BU of 1jdh by Molmil](/molmil-images/mine/1jdh) | CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4 | Descriptor: | BETA-CATENIN, hTcf-4 | Authors: | Graham, T.A, Ferkey, D.M, Mao, F, Kimelman, D, Xu, W. | Deposit date: | 2001-06-13 | Release date: | 2001-12-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat.Struct.Biol., 8, 2001
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8RU3
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![BU of 8ru3 by Molmil](/molmil-images/mine/8ru3) | Crystal structure of beta-catenin in complex with alpha-helical peptide inhibitor | Descriptor: | Axin-1, CHLORIDE ION, Catenin beta-1 | Authors: | Yeste Vazquez, A, Klintrot, C.I.R, Grossmann, T.N, Hennig, S. | Deposit date: | 2024-01-30 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin. Angew.Chem.Int.Ed.Engl., 2024
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6M90
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![BU of 6m90 by Molmil](/molmil-images/mine/6m90) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex | Descriptor: | 2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... | Authors: | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. | Deposit date: | 2018-08-22 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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1T08
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![BU of 1t08 by Molmil](/molmil-images/mine/1t08) | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | Descriptor: | Adenomatous polyposis coli protein, Beta-catenin, Beta-catenin-interacting protein 1 | Authors: | Ha, N.-C, Tonozuka, T, Stamos, J.L, Weis, W.I. | Deposit date: | 2004-04-07 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation Mol.Cell, 15, 2004
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1G3J
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![BU of 1g3j by Molmil](/molmil-images/mine/1g3j) | CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX | Descriptor: | BETA-CATENIN ARMADILLO REPEAT REGION, TCF3-CBD (CATENIN BINDING DOMAIN) | Authors: | Graham, T.A, Weaver, C, Mao, F, Kimelman, D, Xu, W. | Deposit date: | 2000-10-24 | Release date: | 2000-12-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a beta-catenin/Tcf complex. Cell(Cambridge,Mass.), 103, 2000
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3DIW
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![BU of 3diw by Molmil](/molmil-images/mine/3diw) | c-terminal beta-catenin bound TIP-1 structure | Descriptor: | Tax1-binding protein 3, decameric peptide form Catenin beta-1 | Authors: | Shen, Y. | Deposit date: | 2008-06-21 | Release date: | 2008-10-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis of beta-Catenin Recognition by Tax-interacting Protein-1 J.Mol.Biol., 384, 2008
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8RU4
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![BU of 8ru4 by Molmil](/molmil-images/mine/8ru4) | Crystal structure of Human Catenin Beta-1 in complex with stitched peptide inhibitor | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Axin-1, CHLORIDE ION, ... | Authors: | Yeste Vazquez, A, Klintrot, C.I.R, Grossmann, T.N, Hennig, S. | Deposit date: | 2024-01-30 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin. Angew.Chem.Int.Ed.Engl., 2024
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6O9B
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3SL9
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![BU of 3sl9 by Molmil](/molmil-images/mine/3sl9) | X-ray structure of Beta catenin in complex with Bcl9 | Descriptor: | 1,2-ETHANEDIOL, B-cell CLL/lymphoma 9 protein, Catenin beta-1, ... | Authors: | Gupta, D, Bienz, M. | Deposit date: | 2011-06-24 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 2012
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6WLX
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2Z6H
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![BU of 2z6h by Molmil](/molmil-images/mine/2z6h) | Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | Descriptor: | Catenin beta-1 | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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1QZ7
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![BU of 1qz7 by Molmil](/molmil-images/mine/1qz7) | Beta-catenin binding domain of Axin in complex with beta-catenin | Descriptor: | Axin, Beta-catenin | Authors: | Xing, Y, Clements, W.K, Kimelman, D, Xu, W. | Deposit date: | 2003-09-15 | Release date: | 2003-11-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the {beta}-catenin destruction complex GENES DEV., 17, 2003
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8Z0U
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8VME
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![BU of 8vme by Molmil](/molmil-images/mine/8vme) | Crystal structure of the GSK-3/Axin complex bound to a phosphorylated beta-catenin T41A peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Axin-1, Catenin beta-1, ... | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | Deposit date: | 2024-01-13 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK3beta Sci.Signal., 2024
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7UWI
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![BU of 7uwi by Molmil](/molmil-images/mine/7uwi) | Structure of beta-catenin in complex with FP01567, a Helicon Polypeptide | Descriptor: | Catenin beta-1, GLYCEROL, Helicon Polypeptide FP01567, ... | Authors: | Brennan, M, Agarwal, S, Thomson, T, Wahl, S, Ramirez, J, Verdine, G, McGee, J. | Deposit date: | 2022-05-03 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
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8Z10
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![BU of 8z10 by Molmil](/molmil-images/mine/8z10) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1, PROLINE | Authors: | Tim, F. | Deposit date: | 2024-04-10 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of Beta-catenin To Be Published
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6M92
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![BU of 6m92 by Molmil](/molmil-images/mine/6m92) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex | Descriptor: | 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... | Authors: | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J, Lee, S.J. | Deposit date: | 2018-08-22 | Release date: | 2019-04-03 | Last modified: | 2020-01-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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6M91
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![BU of 6m91 by Molmil](/molmil-images/mine/6m91) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex | Descriptor: | 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid, CHLORIDE ION, Catenin beta-1, ... | Authors: | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. | Deposit date: | 2018-08-22 | Release date: | 2019-04-03 | Last modified: | 2019-04-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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6O9C
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8Z61
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![BU of 8z61 by Molmil](/molmil-images/mine/8z61) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-04-18 | Release date: | 2024-05-08 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 67, 2024
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8VMF
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![BU of 8vmf by Molmil](/molmil-images/mine/8vmf) | Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin S45D peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Axin-1, ... | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | Deposit date: | 2024-01-13 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK3beta Sci.Signal., 2024
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8Y0G
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![BU of 8y0g by Molmil](/molmil-images/mine/8y0g) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-01-22 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal protein of human Beta-catenin To Be Published
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