6M90

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex

Summary for 6M90

Entry DOI	10.2210/pdb6m90/pdb
Descriptor	F-box/WD repeat-containing protein 1A, Skp1, Catenin beta-1, ... (6 entities in total)
Functional Keywords	ubiquitin molecular glue enhancer, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	70390.48
Authors	Simonetta, K.R.,Clifton, M.C.,Walter, R.L.,Ranieri, G.M.,Carter, J.J. (deposition date: 2018-08-22, release date: 2019-04-03, Last modification date: 2023-10-11)
Primary citation	Simonetta, K.R.,Taygerly, J.,Boyle, K.,Basham, S.E.,Padovani, C.,Lou, Y.,Cummins, T.J.,Yung, S.L.,von Soly, S.K.,Kayser, F.,Kuriyan, J.,Rape, M.,Cardozo, M.,Gallop, M.A.,Bence, N.F.,Barsanti, P.A.,Saha, A. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10:1402-1402, 2019 Cited by PubMed: 30926793 DOI: 10.1038/s41467-019-09358-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation