6M90

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	F-box/WD repeat-containing protein 1A	polymer	432	49418.4	1	UniProt (Q9Y297) Pfam (PF12937) Pfam (PF00400)	Homo sapiens (Human)	E3RSIkappaB,Epididymis tissue protein Li 2a,F-box and WD repeats protein beta-TrCP,pIkappaBalpha-E3 receptor subunit
2	B (B)	Skp1	polymer	144	16459.7	1	UniProt (P63208) Pfam (PF01466) Pfam (PF03931)	Homo sapiens
3	C (C)	Catenin beta-1	polymer	33	3544.7	1	UniProt (P35222)	Homo sapiens	Beta-catenin
4	D, E (A)	2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid	non-polymer		436.3	2	Chemie (J91)
5	F (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	G, H, I (A, B, C)	water	water		18.0	74	Chemie (HOH)

Sequence modifications

A: 139 - 569 (UniProt: Q9Y297)

PDB	External Database	Details
Ser 138	-	expression tag

B: 2 - 145 (UniProt: P63208)

PDB	External Database	Details
-	Asp 37	deletion
-	Asp 38	deletion
-	Glu 39	deletion
-	Gly 40	deletion
-	Asp 41	deletion
-	Asp 42	deletion
-	Pro 71	deletion
-	Pro 72	deletion
-	Glu 73	deletion
-	Asp 74	deletion
-	Asp 75	deletion
-	Glu 76	deletion
-	Asn 77	deletion
-	Lys 78	deletion
-	Glu 79	deletion
-	Lys 80	deletion
-	Arg 81	deletion
-	Thr 82	deletion

C: 17 - 48 (UniProt: P35222)

PDB	External Database	Details
Cys 16	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	69422.9
Non-Polymers*	Number of molecules	3
	Total formula weight	967.6
All*	Total formula weight	70390.5

*Water molecules are not included.