7ALC
| human GCH-GFRP stimulatory complex | Descriptor: | GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, ... | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-10-06 | Release date: | 2021-10-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.726 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALA
| human GCH-GFRP inhibitory complex | Descriptor: | 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-10-06 | Release date: | 2021-10-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALB
| human GCH-GFRP stimulatory complex 7-deaza-GTP bound | Descriptor: | 7-deaza-GTP, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-10-06 | Release date: | 2021-10-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.979 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALQ
| human GCH-GFRP inhibitory complex 7-deaza-GTP bound | Descriptor: | 7,8-DIHYDROBIOPTERIN, 7-deaza-GTP, GTP cyclohydrolase 1, ... | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-10-07 | Release date: | 2021-10-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.205 Å) | Cite: | Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. J.Struct.Biol., 213, 2021
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6Z86
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6Z89
| human GTP cyclohydrolase I in complex with allosteric inhibitor | Descriptor: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.366 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z87
| human GTP cyclohydrolase I | Descriptor: | GTP cyclohydrolase 1, ZINC ION | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.564 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z88
| human GTP cyclohydrolase I in complex with allosteric inhibitor | Descriptor: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.687 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z85
| inhibitory human GTP cyclohydrolase I - GFRP complex | Descriptor: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | Authors: | Ebenhoch, R, Nar, H, Vonck, J. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z80
| stimulatory human GTP cyclohydrolase I - GFRP complex | Descriptor: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | Authors: | Ebenhoch, R, Nar, H, Vonck, J. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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1FB1
| CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I | Descriptor: | GTP CYCLOHYDROLASE I, ISOPROPYL ALCOHOL, ZINC ION | Authors: | Auerbach, G, Herrmann, A, Bracher, A, Bader, G, Gutlich, M, Fischer, M, Neukamm, M, Nar, H, Garrido-Franco, M, Richardson, J, Huber, R, Bacher, A. | Deposit date: | 2000-07-14 | Release date: | 2000-12-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Zinc plays a key role in human and bacterial GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 97, 2000
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