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PDB: 55 results
6ICG
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BU of 6icg by Molmil
Grb2 SH2 domain in phosphopeptide free form
Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019
3WA4
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BU of 3wa4 by Molmil
Grb2 SH2 domain/CD28-derived peptide complex
Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Higo, K, Oda, M, Ito, N.
Deposit date:2013-04-23
Release date:2014-02-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28
Plos One, 8, 2013
1JYR
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BU of 1jyr by Molmil
Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide
Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN
Authors:Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A.
Deposit date:2001-09-13
Release date:2002-03-13
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
2VWF
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BU of 2vwf by Molmil
Grb2 SH3C (2)
Descriptor: GRB2-ASSOCIATED-BINDING PROTEIN 2, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-06-24
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
2VVK
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BU of 2vvk by Molmil
Grb2 SH3C (1)
Descriptor: GLYCEROL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-06-09
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
3OV1
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BU of 3ov1 by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Martin, S.F.
Deposit date:2010-09-15
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
4P9V
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BU of 4p9v by Molmil
Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2
Authors:Clements, J.H, Martin, S.F.
Deposit date:2014-04-06
Release date:2014-06-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.
Bioorg.Med.Chem.Lett., 24, 2014
1GCQ
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BU of 1gcq by Molmil
CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, VAV PROTO-ONCOGENE
Authors:Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F.
Deposit date:2000-08-08
Release date:2001-08-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Novel recognition mode between Vav and Grb2 SH3 domains.
EMBO J., 20, 2001
2W0Z
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BU of 2w0z by Molmil
Grb2 SH3C (3)
Descriptor: GRB2-ASSOCIATED-BINDING PROTEIN 2, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-10-13
Release date:2009-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
3C7I
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BU of 3c7i by Molmil
X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.
Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2008-02-07
Release date:2008-08-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 118, 2006
3IN8
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BU of 3in8 by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic
Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide
Authors:Benfield, A.P, Clements, J.H.
Deposit date:2009-08-11
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization.
J.Am.Chem.Soc., 131, 2009
3S8N
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BU of 3s8n by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
3S8L
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BU of 3s8l by Molmil
Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area
Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
1BMB
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BU of 1bmb by Molmil
GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)
Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF270-974)
Authors:Rondeau, J.M, Zurini, M.
Deposit date:1998-07-23
Release date:1998-07-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).
J.Med.Chem., 42, 1999
4P9Z
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BU of 4p9z by Molmil
Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Clements, J.H, Martin, S.F.
Deposit date:2014-04-06
Release date:2014-06-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.
Bioorg.Med.Chem.Lett., 24, 2014
6WM1
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BU of 6wm1 by Molmil
Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl
Descriptor: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ...
Authors:Martin, S.F, Clements, J.H.
Deposit date:2020-04-20
Release date:2020-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions.
Eur.J.Med.Chem., 208, 2020
1ZFP
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BU of 1zfp by Molmil
GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE
Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION
Authors:Rahuel, J.
Deposit date:1998-03-26
Release date:1999-03-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.
J.Mol.Biol., 279, 1998
2AOB
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BU of 2aob by Molmil
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, Growth factor receptor-bound protein 2
Authors:Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S.
Deposit date:2005-08-12
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353, 2005
3OVE
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BU of 3ove by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN
Authors:Clements, J.H, Martin, S.F.
Deposit date:2010-09-16
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
3S8O
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BU of 3s8o by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
2H46
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BU of 2h46 by Molmil
Native domain-swapped dimer crystal structure of the Grb2 SH2 domain
Descriptor: GLYCEROL, Growth Receptor Binding Protein 2
Authors:Benfield, A.P, Martin, S.F, Whiddon, B.B.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2HUW
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BU of 2huw by Molmil
X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Descriptor: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2006-07-27
Release date:2006-08-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45, 2006
2AOA
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BU of 2aoa by Molmil
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Growth factor receptor-bound protein 2
Authors:Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S.
Deposit date:2005-08-12
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353, 2005
1JYQ
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BU of 1jyq by Molmil
Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide
Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor
Authors:Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A.
Deposit date:2001-09-13
Release date:2002-03-13
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
6WO2
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BU of 6wo2 by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl
Descriptor: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Martin, S.F, Clements, J.H.
Deposit date:2020-04-24
Release date:2020-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions.
Eur.J.Med.Chem., 208, 2020

 

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