7KH8
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![BU of 7kh8 by Molmil](/molmil-images/mine/7kh8) | Human LMPTP in complex with inhibitor | Descriptor: | 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION | Authors: | Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B. | Deposit date: | 2020-10-20 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J.Med.Chem., 64, 2021
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5KQL
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5JNT
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![BU of 5jnt by Molmil](/molmil-images/mine/5jnt) | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5KQG
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7UW6
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![BU of 7uw6 by Molmil](/molmil-images/mine/7uw6) | The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2 | Descriptor: | 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.Y. | Deposit date: | 2022-05-02 | Release date: | 2022-10-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J.Med.Chem., 65, 2022
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3N8I
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1XWW
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6Y2W
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5JNS
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![BU of 5jns by Molmil](/molmil-images/mine/5jns) | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate | Descriptor: | DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5KQM
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![BU of 5kqm by Molmil](/molmil-images/mine/5kqm) | Co-crystal structure of LMW-PTP in complex with MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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5JNR
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![BU of 5jnr by Molmil](/molmil-images/mine/5jnr) | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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6Y2V
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5KQP
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![BU of 5kqp by Molmil](/molmil-images/mine/5kqp) | Crystal structure of Apo-form LMW-PTP | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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4Z9A
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![BU of 4z9a by Molmil](/molmil-images/mine/4z9a) | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with phenylmethanesulfonic acid | Descriptor: | GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase, SULFATE ION, ... | Authors: | Trivella, D.B.B, Fonseca, E.M.B, Scorsato, V, Dias, M.P, Aparicio, R. | Deposit date: | 2015-04-10 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg.Med.Chem., 23, 2015
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5PNT
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![BU of 5pnt by Molmil](/molmil-images/mine/5pnt) | CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE | Authors: | Zhang, M, Stauffacher, C, Lin, D, Vanetten, R. | Deposit date: | 1998-04-29 | Release date: | 1998-10-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. J.Biol.Chem., 273, 1998
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4Z99
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![BU of 4z99 by Molmil](/molmil-images/mine/4z99) | Crystal structure of the apo Low Molecular Weight Protein Tyrosine Phosphatase isoform A | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Fonseca, E.M.B, Scorsato, V, Dias, M.P, de Oliveria, F.L, Miranda, P.C.M.L, Aparicio, R. | Deposit date: | 2015-04-10 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg.Med.Chem., 23, 2015
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4Z9B
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![BU of 4z9b by Molmil](/molmil-images/mine/4z9b) | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with benzylphosphonic acid | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase, benzylphosphonic acid | Authors: | Fonseca, E.M.B, Trivella, D.B.B, Scorsato, V, Dias, M.P, de Oliveira, F.L, Miranda, P.C.M.L, Aparicio, R. | Deposit date: | 2015-04-10 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg.Med.Chem., 23, 2015
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