7UW6

The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2

Summary for 7UW6

Entry DOI	10.2210/pdb7uw6/pdb
Descriptor	Low molecular weight phosphotyrosine protein phosphatase, 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid (3 entities in total)
Functional Keywords	low molecular weight protein tyrosine phosphatase; inhibitor; complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20377.98
Authors	Wang, J.,Zhang, Z.Y. (deposition date: 2022-05-02, release date: 2022-10-19, Last modification date: 2023-10-18)
Primary citation	He, R.,Wang, J.,Yu, Z.H.,Moyers, J.S.,Michael, M.D.,Durham, T.B.,Cramer, J.W.,Qian, Y.,Lin, A.,Wu, L.,Noinaj, N.,Barrett, D.G.,Zhang, Z.Y. Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J.Med.Chem., 65:13892-13909, 2022 Cited by PubMed: 36197449 DOI: 10.1021/acs.jmedchem.2c01143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation