7UW6

The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Low molecular weight phosphotyrosine protein phosphatase	polymer	177	20105.7	1	UniProt (P24666) Pfam (PF01451) In PDB	Homo sapiens (human)	LMW-PTP,LMW-PTPase,Adipocyte acid phosphatase,Low molecular weight cytosolic acid phosphatase,Red cell acid phosphatase 1
2	A	2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid	non-polymer		272.3	1	Chemie (OIF)
3		water	water		18.0	219	Chemie (HOH)

Sequence modifications

A: 1 - 157 (UniProt: P24666)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20105.7
Non-Polymers*	Number of molecules	1
	Total formula weight	272.3
All*	Total formula weight	20378.0

*Water molecules are not included.