4Z9B

Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with benzylphosphonic acid

Summary for 4Z9B

Entry DOI	10.2210/pdb4z9b/pdb
Related	3N8I 4Z99 4Z9A 5PNT
Descriptor	Low molecular weight phosphotyrosine protein phosphatase, benzylphosphonic acid (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, hydrolase, protein-ligand complex, benzylphosphonic acid
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18927.39
Authors	Fonseca, E.M.B.,Trivella, D.B.B.,Scorsato, V.,Dias, M.P.,de Oliveira, F.L.,Miranda, P.C.M.L.,Aparicio, R. (deposition date: 2015-04-10, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citation	Fonseca, E.M.,Trivella, D.B.,Scorsato, V.,Dias, M.P.,Bazzo, N.L.,Mandapati, K.R.,de Oliveira, F.L.,Ferreira-Halder, C.V.,Pilli, R.A.,Miranda, P.C.,Aparicio, R. Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg.Med.Chem., 23:4462-4471, 2015 Cited by PubMed: 26117648 DOI: 10.1016/j.bmc.2015.06.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation