8FRX
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![BU of 8frx by Molmil](/molmil-images/mine/8frx) | Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | Authors: | Felt, K.C, Chakrapani, S. | Deposit date: | 2023-01-09 | Release date: | 2023-12-27 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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8FRZ
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8FSB
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![BU of 8fsb by Molmil](/molmil-images/mine/8fsb) | |
6Y5A
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![BU of 6y5a by Molmil](/molmil-images/mine/6y5a) | Serotonin-bound 5-HT3A receptor in Salipro | Descriptor: | 5-hydroxytryptamine receptor 3A, SEROTONIN | Authors: | Zhang, Y, Dijkman, P.M, Zou, R, Zandl-Lang, M, Sanchez, R.M, Eckhardt-Strelau, L, Koefeler, H, Vogel, H, Yuan, S, Kudryashev, M. | Deposit date: | 2020-02-25 | Release date: | 2020-12-23 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Asymmetric opening of the homopentameric 5-HT 3A serotonin receptor in lipid bilayers. Nat Commun, 12, 2021
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6Y1Z
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![BU of 6y1z by Molmil](/molmil-images/mine/6y1z) | Mouse serotonin 5HT3 receptor in complex with palonosetron | Descriptor: | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zarkadas, E, Perot, J, Nury, H. | Deposit date: | 2020-02-14 | Release date: | 2020-03-04 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | The Binding of Palonosetron and Other Antiemetic Drugs to the Serotonin 5-HT3 Receptor. Structure, 28, 2020
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6W1J
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![BU of 6w1j by Molmil](/molmil-images/mine/6w1j) | Cryo-EM structure of 5HT3A receptor in presence of Alosetron | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2020-03-04 | Release date: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
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8FRW
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![BU of 8frw by Molmil](/molmil-images/mine/8frw) | Full-length mouse 5-HT3A receptor in complex with ALB148471, pre-activated | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | Authors: | Felt, K.C, Chakrapani, S. | Deposit date: | 2023-01-09 | Release date: | 2023-12-27 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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6NP0
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![BU of 6np0 by Molmil](/molmil-images/mine/6np0) | Cryo-EM structure of 5HT3A receptor in presence of granisetron | Descriptor: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2019-01-17 | Release date: | 2019-07-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor. Nat Commun, 10, 2019
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8CC7
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![BU of 8cc7 by Molmil](/molmil-images/mine/8cc7) | Mouse serotonin 5-HT3A receptor in complex with PZ-1939 | Descriptor: | 1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2023-01-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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8AW2
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![BU of 8aw2 by Molmil](/molmil-images/mine/8aw2) | Mouse serotonin 5-HT3A receptor in complex with vortioxetine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2022-08-29 | Release date: | 2024-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
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6W1M
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![BU of 6w1m by Molmil](/molmil-images/mine/6w1m) | Cryo-EM structure of 5HT3A receptor in presence of Ondansetron | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2020-03-04 | Release date: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
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6Y5B
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![BU of 6y5b by Molmil](/molmil-images/mine/6y5b) | 5-HT3A receptor in Salipro (apo, asymmetric) | Descriptor: | 5-hydroxytryptamine receptor 3A | Authors: | Zhang, Y, Dijkman, P.M, Zou, R, Zandl-Lang, M, Sanchez, R.M, Eckhardt-Strelau, L, Koefeler, H, Vogel, H, Yuan, S, Kudryashev, M. | Deposit date: | 2020-02-25 | Release date: | 2020-12-23 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Asymmetric opening of the homopentameric 5-HT 3A serotonin receptor in lipid bilayers. Nat Commun, 12, 2021
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6Y59
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![BU of 6y59 by Molmil](/molmil-images/mine/6y59) | 5-HT3A receptor in Salipro (apo, C5 symmetric) | Descriptor: | 5-hydroxytryptamine receptor 3A | Authors: | Zhang, Y, Dijkman, P.M, Zou, R, Zandl-Lang, M, Sanchez, R.M, Eckhardt-Strelau, L, Koefeler, H, Vogel, H, Yuan, S, Kudryashev, M. | Deposit date: | 2020-02-25 | Release date: | 2020-12-23 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Asymmetric opening of the homopentameric 5-HT 3A serotonin receptor in lipid bilayers. Nat Commun, 12, 2021
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8CC6
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![BU of 8cc6 by Molmil](/molmil-images/mine/8cc6) | Mouse serotonin 5-HT3A receptor in complex with PZ-1922 | Descriptor: | 1-[(3-chlorophenyl)methyl]-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2023-01-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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6HIQ
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![BU of 6hiq by Molmil](/molmil-images/mine/6hiq) | Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | Deposit date: | 2018-08-30 | Release date: | 2018-11-07 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6DG7
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![BU of 6dg7 by Molmil](/molmil-images/mine/6dg7) | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2018-05-17 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor. Nature, 563, 2018
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6W1Y
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![BU of 6w1y by Molmil](/molmil-images/mine/6w1y) | Cryo-EM structure of 5HT3A receptor in presence of Palonosetron | Descriptor: | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2020-03-04 | Release date: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
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8C20
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4PIR
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![BU of 4pir by Molmil](/molmil-images/mine/4pir) | X-ray structure of the mouse serotonin 5-HT3 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Hassaine, G, Deluz, C, Grasso, L, Wyss, R, Tol, M.B, Hovius, R, Graff, A, Stahlberg, H, Tomizaki, T, Desmyter, A, Moreau, C, Li, X.-D, Poitevin, F, Vogel, H, Nury, H. | Deposit date: | 2014-05-09 | Release date: | 2014-08-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | X-ray structure of the mouse serotonin 5-HT3 receptor. Nature, 512, 2014
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8C21
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8FSP
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![BU of 8fsp by Molmil](/molmil-images/mine/8fsp) | Full-length mouse 5-HT3A receptor in complex with SMP100, open-like | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | Authors: | Felt, K.C, Chakrapani, S. | Deposit date: | 2023-01-10 | Release date: | 2023-12-27 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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8FSZ
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![BU of 8fsz by Molmil](/molmil-images/mine/8fsz) | Full-length mouse 5-HT3A receptor in complex with ALB148471, open-like | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | Authors: | Felt, K.C, Chakrapani, S. | Deposit date: | 2023-01-11 | Release date: | 2023-12-27 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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8C1Z
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![BU of 8c1z by Molmil](/molmil-images/mine/8c1z) | |
6DG8
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![BU of 6dg8 by Molmil](/molmil-images/mine/6dg8) | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2018-05-17 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor. Nature, 563, 2018
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8C1W
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![BU of 8c1w by Molmil](/molmil-images/mine/8c1w) | |