8FSP

Full-length mouse 5-HT3A receptor in complex with SMP100, open-like

Summary for 8FSP

Entry DOI	10.2210/pdb8fsp/pdb
EMDB information	29409 29410 29411 29418 29421
Descriptor	5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one (3 entities in total)
Functional Keywords	partial agonist, cys-loop, plgic, ion channel, transport protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	5
Total formula weight	316549.02
Authors	Felt, K.C.,Chakrapani, S. (deposition date: 2023-01-10, release date: 2023-12-27, Last modification date: 2024-01-17)
Primary citation	Felt, K.,Stauffer, M.,Salas-Estrada, L.,Guzzo, P.R.,Xie, D.,Huang, J.,Filizola, M.,Chakrapani, S. Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38177669 DOI: 10.1038/s41594-023-01140-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.79 Å)

Structure validation