8FSP

Full-length mouse 5-HT3A receptor in complex with SMP100, open-like

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (A, B, C, D, E)	5-hydroxytryptamine receptor 3A	polymer	553	62349.8	5	UniProt (E9QLC0) Pfam (PF02931) Pfam (PF02932) UniProt (by SIFTS) (P23979)	Mus musculus (house mouse)
2	F, G, H, J, K... (A, B, C, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)
3	I, M, Q, U, V (A, B, C, D, E)	5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one	non-polymer		296.4	5	Chemie (Y82)

Sequence modifications

A, B, C, D, E: 1 - 462 (UniProt: E9QLC0)

PDB	External Database	Details
Trp -74	-	expression tag
Ser -73	-	expression tag
His -72	-	expression tag
Pro -71	-	expression tag
Gln -70	-	expression tag
Phe -69	-	expression tag
Glu -68	-	expression tag
Lys -67	-	expression tag
Gly -66	-	expression tag
Gly -65	-	expression tag
Gly -64	-	expression tag
Ser -63	-	expression tag
Gly -62	-	expression tag
Gly -61	-	expression tag
Gly -60	-	expression tag
Ser -59	-	expression tag
Gly -58	-	expression tag
Gly -57	-	expression tag
Gly -56	-	expression tag
Ser -55	-	expression tag
Trp -54	-	expression tag
Ser -53	-	expression tag
His -52	-	expression tag
Pro -51	-	expression tag
Gln -50	-	expression tag
Phe -49	-	expression tag
Glu -48	-	expression tag
Lys -47	-	expression tag
Gly -46	-	expression tag
Gly -45	-	expression tag
Gly -44	-	expression tag
Ser -43	-	expression tag
Gly -42	-	expression tag
Gly -41	-	expression tag
Gly -40	-	expression tag
Ser -39	-	expression tag
Gly -38	-	expression tag
Gly -37	-	expression tag
Gly -36	-	expression tag
Ser -35	-	expression tag
Trp -34	-	expression tag
Ser -33	-	expression tag
His -32	-	expression tag
Pro -31	-	expression tag
Gln -30	-	expression tag
Phe -29	-	expression tag
Glu -28	-	expression tag
Lys -27	-	expression tag
Gly -26	-	expression tag
Gly -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Gly -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
Trp -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
Pro -11	-	expression tag
Gln -10	-	expression tag
Phe -9	-	expression tag
Glu -8	-	expression tag
Lys -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Glu 463	-	expression tag
Asn 464	-	expression tag
Leu 465	-	expression tag
Tyr 466	-	expression tag
Phe 467	-	expression tag
Gln 468	-	expression tag
Gly 469	-	expression tag
Thr 470	-	expression tag
Glu 471	-	expression tag
Thr 472	-	expression tag
Ser 473	-	expression tag
Gln 474	-	expression tag
Val 475	-	expression tag
Ala 476	-	expression tag
Pro 477	-	expression tag
Ala 478	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	311749.1
Non-Polymers*	Number of molecules	20
	Total formula weight	4800.0
All*	Total formula weight	316549.0

*Water molecules are not included.