8CC6

Mouse serotonin 5-HT3A receptor in complex with PZ-1922

Summary for 8CC6

• Entry DOI: 10.2210/pdb8cc6/pdb
• EMDB information: 16555
• Descriptor: 5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: ion channel, receptor, plgic, transport protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 5
• Total formula weight: 325648.05

Authors

Lopez-Sanchez, U.,Nury, H. (deposition date: 2023-01-26, release date: 2023-10-11, Last modification date: 2023-11-22)

• Primary citation: Grychowska, K.,Lopez-Sanchez, U.,Vitalis, M.,Canet, G.,Satala, G.,Olejarz-Maciej, A.,Golebiowska, J.,Kurczab, R.,Pietrus, W.,Kubacka, M.,Moreau, C.,Walczak, M.,Blicharz-Futera, K.,Bento, O.,Bantreil, X.,Subra, G.,Bojarski, A.J.,Lamaty, F.,Becamel, C.,Zussy, C.,Chaumont-Dubel, S.,Popik, P.,Nury, H.,Marin, P.,Givalois, L.,Zajdel, P.; Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.; J.Med.Chem., 66:14928-14947, 2023; PubMed: 37797083; DOI: 10.1021/acs.jmedchem.3c01482

Experimental method

ELECTRON MICROSCOPY (3.2 Å)