6W1Y

Cryo-EM structure of 5HT3A receptor in presence of Palonosetron

Summary for 6W1Y

• Entry DOI: 10.2210/pdb6w1y/pdb
• EMDB information: 21511 21512 21518
• Descriptor: 5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transport protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 5
• Total formula weight: 268869.36

Authors

Basak, S.,Chakrapani, S. (deposition date: 2020-03-04, release date: 2021-01-13)

• Primary citation: Basak, S.,Kumar, A.,Ramsey, S.,Gibbs, E.,Kapoor, A.,Filizola, M.,Chakrapani, S.; High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.; Elife, 9:-, 2020; PubMed: 33063666; DOI: 10.7554/eLife.57870

Experimental method

ELECTRON MICROSCOPY (3.35 Å)