Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6W1Y

Cryo-EM structure of 5HT3A receptor in presence of Palonosetron

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0007210	biological_process	serotonin receptor signaling pathway
A	0007268	biological_process	chemical synaptic transmission
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0022850	molecular_function	serotonin-gated monoatomic cation channel activity
A	0032154	cellular_component	cleavage furrow
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0051378	molecular_function	serotonin binding
A	0060078	biological_process	regulation of postsynaptic membrane potential
A	0060079	biological_process	excitatory postsynaptic potential
A	0098662	biological_process	inorganic cation transmembrane transport
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	0140227	biological_process	serotonin-gated cation-selective signaling pathway
A	1902495	cellular_component	transmembrane transporter complex
A	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A	1904602	cellular_component	serotonin-activated cation-selective channel complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0007210	biological_process	serotonin receptor signaling pathway
B	0007268	biological_process	chemical synaptic transmission
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0022850	molecular_function	serotonin-gated monoatomic cation channel activity
B	0032154	cellular_component	cleavage furrow
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0051378	molecular_function	serotonin binding
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0098662	biological_process	inorganic cation transmembrane transport
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	0140227	biological_process	serotonin-gated cation-selective signaling pathway
B	1902495	cellular_component	transmembrane transporter complex
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B	1904602	cellular_component	serotonin-activated cation-selective channel complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0007210	biological_process	serotonin receptor signaling pathway
C	0007268	biological_process	chemical synaptic transmission
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0022850	molecular_function	serotonin-gated monoatomic cation channel activity
C	0032154	cellular_component	cleavage furrow
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0051378	molecular_function	serotonin binding
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0098662	biological_process	inorganic cation transmembrane transport
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	0140227	biological_process	serotonin-gated cation-selective signaling pathway
C	1902495	cellular_component	transmembrane transporter complex
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	1904602	cellular_component	serotonin-activated cation-selective channel complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0007210	biological_process	serotonin receptor signaling pathway
D	0007268	biological_process	chemical synaptic transmission
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0022850	molecular_function	serotonin-gated monoatomic cation channel activity
D	0032154	cellular_component	cleavage furrow
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0045211	cellular_component	postsynaptic membrane
D	0051378	molecular_function	serotonin binding
D	0060078	biological_process	regulation of postsynaptic membrane potential
D	0060079	biological_process	excitatory postsynaptic potential
D	0098662	biological_process	inorganic cation transmembrane transport
D	0099505	biological_process	regulation of presynaptic membrane potential
D	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D	0140227	biological_process	serotonin-gated cation-selective signaling pathway
D	1902495	cellular_component	transmembrane transporter complex
D	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D	1904602	cellular_component	serotonin-activated cation-selective channel complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0007210	biological_process	serotonin receptor signaling pathway
E	0007268	biological_process	chemical synaptic transmission
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0022850	molecular_function	serotonin-gated monoatomic cation channel activity
E	0032154	cellular_component	cleavage furrow
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0051378	molecular_function	serotonin binding
E	0060078	biological_process	regulation of postsynaptic membrane potential
E	0060079	biological_process	excitatory postsynaptic potential
E	0098662	biological_process	inorganic cation transmembrane transport
E	0099505	biological_process	regulation of presynaptic membrane potential
E	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E	0140227	biological_process	serotonin-gated cation-selective signaling pathway
E	1902495	cellular_component	transmembrane transporter complex
E	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E	1904602	cellular_component	serotonin-activated cation-selective channel complex

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC

Chain	Residue	Details
A	CYS135-CYS149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25119048","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	90
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	55
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25119048","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	90
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	95
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	180
Details	Region: {"description":"HA-stretch; determines single-channel conductance in 5-HT3 receptors","evidences":[{"source":"UniProtKB","id":"P46098","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)