6W1Y
Cryo-EM structure of 5HT3A receptor in presence of Palonosetron
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | 5-hydroxytryptamine receptor 3A | polymer | 450 | 52042.1 | 5 | UniProt (Q8K1F4) Pfam (PF02931) Pfam (PF02932) UniProt (by SIFTS) (P23979) | Mus musculus (Mouse) | 5-hydroxytryptamine receptor 3A short splice variant,Htr3a protein |
| 2 | F, I, L, O, R (F, I, L, O, R) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | ||||
| 3 | G, J, M, P, S (G, J, M, P, S) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | ||||
| 4 | H, K, N, Q, T (H, K, N, Q, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | ||||
| 5 | U, V, W, X, Y (A, B, C, D, E) | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one | non-polymer | 296.4 | 5 | Chemie (O7B) PubChem (148211) PubChem (6337614) PubChem (9882672) PubChem (22866645) PubChem (22866646) PubChem (91903012) PubChem (15656884) PubChem (15656883) PubChem (15656882) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 260210.6 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 7176.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1482.0 | |
| All* | Total formula weight | 268869.4 |
