6NP0

Cryo-EM structure of 5HT3A receptor in presence of granisetron

Summary for 6NP0

• Entry DOI: 10.2210/pdb6np0/pdb
• EMDB information: 0469
• Descriptor: 5-hydroxytryptamine receptor 3A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: membrane protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 5
• Total formula weight: 290284.84

Authors

Basak, S.,Chakrapani, S. (deposition date: 2019-01-17, release date: 2019-07-24, Last modification date: 2020-07-29)

• Primary citation: Basak, S.,Gicheru, Y.,Kapoor, A.,Mayer, M.L.,Filizola, M.,Chakrapani, S.; Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor.; Nat Commun, 10:3225-3225, 2019; PubMed: 31324772; DOI: 10.1038/s41467-019-11142-8

Experimental method

ELECTRON MICROSCOPY (2.92 Å)