6NP0

Cryo-EM structure of 5HT3A receptor in presence of granisetron

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC

Chain	Residue	Details
A	CYS135-CYS149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1165
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048

Chain	Residue	Details
A	SER-3-ARG219
D	SER-3-ARG219
D	ASP271-THR280
D	HIS460-SER462
E	SER-3-ARG219
E	ASP271-THR280
E	HIS460-SER462
A	ASP271-THR280
A	HIS460-SER462
B	SER-3-ARG219
B	ASP271-THR280
B	HIS460-SER462
C	SER-3-ARG219
C	ASP271-THR280
C	HIS460-SER462

---

site_id	SWS_FT_FI2
Number of Residues	130
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	PRO220-PRO246
B	PRO220-PRO246
C	PRO220-PRO246
D	PRO220-PRO246
E	PRO220-PRO246

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site_id	SWS_FT_FI3
Number of Residues	715
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048

Chain	Residue	Details
A	ASP247-ARG251
E	GLU300-ARG439
A	GLU300-ARG439
B	ASP247-ARG251
B	GLU300-ARG439
C	ASP247-ARG251
C	GLU300-ARG439
D	ASP247-ARG251
D	GLU300-ARG439
E	ASP247-ARG251

---

site_id	SWS_FT_FI4
Number of Residues	90
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	VAL252-SER270
B	VAL252-SER270
C	VAL252-SER270
D	VAL252-SER270
E	VAL252-SER270

---

site_id	SWS_FT_FI5
Number of Residues	90
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	PRO281-ALA299
B	PRO281-ALA299
C	PRO281-ALA299
D	PRO281-ALA299
E	PRO281-ALA299

---

site_id	SWS_FT_FI6
Number of Residues	95
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	ILE440-TRP459
B	ILE440-TRP459
C	ILE440-TRP459
D	ILE440-TRP459
E	ILE440-TRP459

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN82
D	ASN82
D	ASN148
D	ASN164
E	ASN82
E	ASN148
E	ASN164
A	ASN148
A	ASN164
B	ASN82
B	ASN148
B	ASN164
C	ASN82
C	ASN148
C	ASN164

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