3RIX
| 1.7A resolution structure of a firefly luciferase-Aspulvinone J inhibitor complex | Descriptor: | (5Z)-4-hydroxy-3-[(2R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]-5-{[(2R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]methylidene}furan-2(5H)-one, Luciferin 4-monooxygenase | Authors: | Lovell, S, Battaile, K.P, Lopez, P.C, Auld, D.S, Schultz, P.J, MacArthur, R, Shen, M, Tamayo, G, Inglese, J, Sherman, D.H. | Deposit date: | 2011-04-14 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors. Chem.Biol., 18, 2011
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3IES
| Firefly luciferase inhibitor complex | Descriptor: | 5'-O-[(R)-[({3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}carbonyl)oxy](hydroxy)phosphoryl]adenosine, Luciferin 4-monooxygenase | Authors: | Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. | Deposit date: | 2009-07-23 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
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1LCI
| FIREFLY LUCIFERASE | Descriptor: | LUCIFERASE | Authors: | Conti, E, Franks, N.P, Brick, P. | Deposit date: | 1996-06-01 | Release date: | 1997-03-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure, 4, 1996
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5GZ2
| luciferase complex with 7-cy-L | Descriptor: | (4S)-2-[6-(azepan-1-yl)-1,3-benzothiazol-2-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid, Luciferin 4-monooxygenase | Authors: | Su, J, Wang, F, Gu, L. | Deposit date: | 2016-09-26 | Release date: | 2017-09-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | luciferase complex with 7-cy-L To Be Published
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5KYT
| Structure of Photinus pyralis Luciferase red light emitting variant | Descriptor: | 1,2-ETHANEDIOL, 5'-O-[N-(DEHYDROLUCIFERYL)-SULFAMOYL] ADENOSINE, Luciferin 4-monooxygenase | Authors: | Gulick, A.M. | Deposit date: | 2016-07-22 | Release date: | 2016-12-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Cloning of the Orange Light-Producing Luciferase from Photinus scintillans-A New Proposal on how Bioluminescence Color is Determined. Photochem. Photobiol., 93, 2017
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3IER
| Firefly luciferase apo structure (P41 form) with PEG 400 bound | Descriptor: | Luciferin 4-monooxygenase, TETRAETHYLENE GLYCOL | Authors: | Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. | Deposit date: | 2009-07-23 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
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3IEP
| Firefly luciferase apo structure (P41 form) | Descriptor: | Luciferin 4-monooxygenase | Authors: | Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. | Deposit date: | 2009-07-23 | Release date: | 2010-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
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1BA3
| FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM | Descriptor: | LUCIFERASE, TRIBROMOMETHANE | Authors: | Franks, N.P, Jenkins, A, Conti, E, Lieb, W.R, Brick, P. | Deposit date: | 1998-04-21 | Release date: | 1998-11-11 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys.J., 75, 1998
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4E5D
| 2.2A resolution structure of a firefly luciferase-benzothiazole inhibitor complex | Descriptor: | 2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole, Luciferin 4-monooxygenase | Authors: | Lovell, S, Battaile, K.P, Throne, N, Shen, M, Auld, D.S, Inglese, J. | Deposit date: | 2012-03-14 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem.Biol., 19, 2012
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5DWV
| Crystal structure of the Luciferase complexed with substrate analogue | Descriptor: | 2-[6-(cyclobuta-1,3-dien-1-ylamino)-1,3-benzothiazol-2-yl]-1,3-thiazol-4-ol, Luciferin 4-monooxygenase | Authors: | Su, J, Li, Z, Yuan, Z, Gu, L. | Deposit date: | 2015-09-23 | Release date: | 2016-09-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Luciferase complexed with substrate analogue To Be Published
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4G37
| Structure of cross-linked firefly luciferase in second catalytic conformation | Descriptor: | 4,4'-(ethylenediimino)bis[4-oxobutyrate], 5'-O-[N-(DEHYDROLUCIFERYL)-SULFAMOYL] ADENOSINE, CHLORIDE ION, ... | Authors: | Sundlov, J.A, Branchini, B.R, Gulick, A.M. | Deposit date: | 2012-07-13 | Release date: | 2012-08-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism. Biochemistry, 51, 2012
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5GYZ
| luciferase AMP/7-cy-L complex | Descriptor: | (4S)-2-[6-(azepan-1-yl)-1,3-benzothiazol-2-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Su, J, Wang, F. | Deposit date: | 2016-09-26 | Release date: | 2017-09-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of luciferase with AMP/7-cy-L at 2.4 Angstroms resolution To Be Published
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5DV9
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5KYV
| Structure of Photinus pyralis Luciferase green shifted light emitting variant | Descriptor: | 5'-O-[N-(DEHYDROLUCIFERYL)-SULFAMOYL] ADENOSINE, L(+)-TARTARIC ACID, Luciferin 4-monooxygenase | Authors: | Gulick, A.M. | Deposit date: | 2016-07-22 | Release date: | 2016-12-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cloning of the Orange Light-Producing Luciferase from Photinus scintillans Provides Insight into Bioluminescence Color Determination To Be Published
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4G36
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6Q2M
| Crystal structure of Photinus pyralis Luciferase Pps6 mutant in complex with DLSA | Descriptor: | (2S,5S)-hexane-2,5-diol, 1,2-ETHANEDIOL, 5'-O-[N-(DEHYDROLUCIFERYL)-SULFAMOYL] ADENOSINE, ... | Authors: | Patel, K.D, Gulick, A.M. | Deposit date: | 2019-08-08 | Release date: | 2019-10-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish thePhotinusLuciferasesscintillansandpyralis. Biochemistry, 58, 2019
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5WYS
| luciferase with inhibitor 3i | Descriptor: | 5-[(3R)-3-(4-boranylphenyl)-3-oxidanyl-propyl]-2-oxidanyl-benzoic acid, Luciferin 4-monooxygenase | Authors: | Gu, L, Su, J, Wang, F. | Deposit date: | 2017-01-15 | Release date: | 2017-12-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.999 Å) | Cite: | Inhibiting Firefly Bioluminescence by Chalcones Anal. Chem., 89, 2017
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6HPS
| Near-infrared dual bioluminescence imaging in vivo using infra-luciferin | Descriptor: | Luciferin 4-monooxygenase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[[2-[(~{E})-2-(6-oxidanyl-1,3-benzothiazol-2-yl)ethenyl]-1,3-thiazol-4-yl]carbonyl]sulfamate | Authors: | Parkinson, G.N, Stowe, C, Anderson, J.C. | Deposit date: | 2018-09-21 | Release date: | 2019-10-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin. Elife, 8, 2019
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