6HPS

Near-infrared dual bioluminescence imaging in vivo using infra-luciferin

Summary for 6HPS

Entry DOI	10.2210/pdb6hps/pdb
Descriptor	Luciferin 4-monooxygenase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[[2-[(~{E})-2-(6-oxidanyl-1,3-benzothiazol-2-yl)ethenyl]-1,3-thiazol-4-yl]carbonyl]sulfamate (2 entities in total)
Functional Keywords	near-infrared bioluminescence imaging, p. pyralis luciferase, anl superfamily, ligase, adenylating enzymes, luciferase, domain alternation, fluorescent protein
Biological source	Photinus pyralis (Common eastern firefly)
Total number of polymer chains	2
Total formula weight	121235.23
Authors	Parkinson, G.N.,Stowe, C.,Anderson, J.C. (deposition date: 2018-09-21, release date: 2019-10-23, Last modification date: 2024-01-24)
Primary citation	Stowe, C.L.,Burley, T.A.,Allan, H.,Vinci, M.,Kramer-Marek, G.,Ciobota, D.M.,Parkinson, G.N.,Southworth, T.L.,Agliardi, G.,Hotblack, A.,Lythgoe, M.F.,Branchini, B.R.,Kalber, T.L.,Anderson, J.C.,Pule, M.A. Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin. Elife, 8:-, 2019 Cited by PubMed: 31610848 DOI: 10.7554/eLife.45801 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation