4E5D
2.2A resolution structure of a firefly luciferase-benzothiazole inhibitor complex
Summary for 4E5D
Entry DOI | 10.2210/pdb4e5d/pdb |
Descriptor | Luciferin 4-monooxygenase, 2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole (3 entities in total) |
Functional Keywords | oxidoreductase, monooxygenase, photoprotein, luminescence, profiling, pubchem, luciferase, quantitative high-throughput screening, qhts, firefly luciferase, reporter-gene assays, adenylate forming enzymes, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Photinus pyralis (North American firefly) |
Cellular location | Peroxisome : P08659 |
Total number of polymer chains | 1 |
Total formula weight | 61078.25 |
Authors | Lovell, S.,Battaile, K.P.,Throne, N.,Shen, M.,Auld, D.S.,Inglese, J. (deposition date: 2012-03-14, release date: 2012-09-05, Last modification date: 2023-09-13) |
Primary citation | Thorne, N.,Shen, M.,Lea, W.A.,Simeonov, A.,Lovell, S.,Auld, D.S.,Inglese, J. Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem.Biol., 19:1060-1072, 2012 Cited by PubMed: 22921073DOI: 10.1016/j.chembiol.2012.07.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.201 Å) |
Structure validation
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