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PDB: 126 results

1G6X
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ULTRA HIGH RESOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE
Descriptor: 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION
Authors:Addlagatta, A, Czapinska, H, Krzywda, S, Otlewski, J, Jaskolski, M.
Deposit date:2000-11-08
Release date:2001-05-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (0.86 Å)
Cite:Ultrahigh-resolution structure of a BPTI mutant.
Acta Crystallogr.,Sect.D, 57, 2001
5PTI
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STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT OF CRYSTAL FORM II
Descriptor: PHOSPHATE ION, TRYPSIN INHIBITOR, UNKNOWN ATOM OR ION
Authors:Wlodawer, A, Huber, R.
Deposit date:1984-10-05
Release date:1984-10-29
Last modified:2018-10-24
Method:NEUTRON DIFFRACTION (1 Å), X-RAY DIFFRACTION
Cite:Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray refinement of crystal form II
J.Mol.Biol., 180, 1984
1K6U
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Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor
Descriptor: 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION
Authors:Botos, I, Wu, Z, Lu, W, Wlodawer, A.
Deposit date:2001-10-17
Release date:2001-12-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.
FEBS Lett., 509, 2001
2ZJX
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Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y.
Deposit date:2008-03-11
Release date:2008-10-21
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines
Proc.Natl.Acad.Sci.Usa, 105, 2008
1BPI
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BU of 1bpi by Molmil
THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Parkin, S, Rupp, B, Hope, H.
Deposit date:1995-02-18
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Structure of bovine pancreatic trypsin inhibitor at 125 K definition of carboxyl-terminal residues Gly57 and Ala58.
Acta Crystallogr.,Sect.D, 52, 1996
2ZVX
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Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y.
Deposit date:2008-11-24
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations
Proteins, 77, 2009
5XX3
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A BPTI-[5,55] variant with C14GA38G mutations
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
5XX2
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A BPTI-[5,55] variant with C14GA38L mutations
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
7PH1
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BU of 7ph1 by Molmil
Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Loll, B.
Deposit date:2021-08-16
Release date:2022-03-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment.
J.Phys.Chem.B, 126, 2022
9PTI
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BASIC PANCREATIC TRYPSIN INHIBITOR (MET 52 OXIDIZED)
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1991-04-08
Release date:1992-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:

4Y0Y
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Trypsin in complex with with BPTI
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
3P95
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Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17D)
Descriptor: CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor
Authors:Salameh, M.A, Soares, A.S, Radisky, E.S.
Deposit date:2010-10-15
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.2991 Å)
Cite:The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.
Biochem.J., 440, 2011
4Y11
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BU of 4y11 by Molmil
Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
5XX8
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BU of 5xx8 by Molmil
Hetero-micro-seeding: Crystal structure of BPTI-[555]C14GA38I variant using micro-seeds from -C14GA38L variant
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A hetero-micro-seeding strategy for readily crystallizing closely related protein variants
Biochem. Biophys. Res. Commun., 493, 2017
3WNY
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A simplified BPTI variant with poly Lys amino acid tag (C3K) at the C-terminus
Descriptor: Bovine Pancreatic Trypsin Inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2013-12-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A simplified BPTI variant with poly Lys amino acid tag (C3K) at the C-terminus
to be published
5XX6
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BU of 5xx6 by Molmil
Hetero-micro-seeding: Crystal structure of BPTI-[5,55]C14GA38I variant using micro-seeds from -C14GA38G variant
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:A hetero-micro-seeding strategy for readily crystallizing closely related protein variants
Biochem. Biophys. Res. Commun., 493, 2017
1P2J
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BU of 1p2j by Molmil
Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
Descriptor: CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O.
Deposit date:2003-04-15
Release date:2004-04-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
J.Mol.Biol., 333, 2003
4Y10
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BU of 4y10 by Molmil
Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
4Y0Z
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BU of 4y0z by Molmil
Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
5XX5
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BU of 5xx5 by Molmil
A BPTI-[5,55] variant with C14GA38I mutations
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
5XX7
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BU of 5xx7 by Molmil
Hetero-micro-seeding: Crystal structure of BPTI-[5,55]C14GA38I variant using micro-seeds from -C14GA38I variant
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:A hetero-micro-seeding strategy for readily crystallizing closely related protein variants
Biochem. Biophys. Res. Commun., 493, 2017
2R9P
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Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor(BPTI)
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION, Trypsin-3
Authors:Salameh, M.A, Soares, A.S, Radisky, E.S.
Deposit date:2007-09-13
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008
4DG4
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BU of 4dg4 by Molmil
Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI)
Descriptor: CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor, ...
Authors:Salameh, M.A, Soares, A.S, Radisky, E.S.
Deposit date:2012-01-24
Release date:2012-09-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
Protein Sci., 21, 2012
1QLQ
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Bovine Pancreatic Trypsin Inhibitor (BPTI) Mutant with Altered Binding Loop Sequence
Descriptor: PANCREATIC TRYPSIN INHIBITOR, SULFATE ION
Authors:Czapinska, H, Krzywda, S, Sheldrick, G.M, Otlewski, J, Jaskolski, M.
Deposit date:1999-09-10
Release date:1999-10-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:High Resolution Structure of Bovine Pancreatic Trypsin Inhibitor with Altered Binding Loop Sequence
J.Mol.Biol., 295, 1999
2RA3
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BU of 2ra3 by Molmil
Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
Descriptor: CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Salameh, M.A, Soares, A.S, Radisky, E.S.
Deposit date:2007-09-14
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008

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