1G6X
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![BU of 1g6x by Molmil](/molmil-images/mine/1g6x) | ULTRA HIGH RESOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE | Descriptor: | 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | Authors: | Addlagatta, A, Czapinska, H, Krzywda, S, Otlewski, J, Jaskolski, M. | Deposit date: | 2000-11-08 | Release date: | 2001-05-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (0.86 Å) | Cite: | Ultrahigh-resolution structure of a BPTI mutant. Acta Crystallogr.,Sect.D, 57, 2001
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1K6U
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![BU of 1k6u by Molmil](/molmil-images/mine/1k6u) | Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor | Descriptor: | 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | Authors: | Botos, I, Wu, Z, Lu, W, Wlodawer, A. | Deposit date: | 2001-10-17 | Release date: | 2001-12-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor. FEBS Lett., 509, 2001
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5PTI
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![BU of 5pti by Molmil](/molmil-images/mine/5pti) | |
1BPI
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![BU of 1bpi by Molmil](/molmil-images/mine/1bpi) | |
2ZJX
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![BU of 2zjx by Molmil](/molmil-images/mine/2zjx) | Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | Deposit date: | 2008-03-11 | Release date: | 2008-10-21 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines Proc.Natl.Acad.Sci.Usa, 105, 2008
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2ZVX
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![BU of 2zvx by Molmil](/molmil-images/mine/2zvx) | Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | Deposit date: | 2008-11-24 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations Proteins, 77, 2009
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5XX2
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![BU of 5xx2 by Molmil](/molmil-images/mine/5xx2) | A BPTI-[5,55] variant with C14GA38L mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5XX3
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![BU of 5xx3 by Molmil](/molmil-images/mine/5xx3) | A BPTI-[5,55] variant with C14GA38G mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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7PH1
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![BU of 7ph1 by Molmil](/molmil-images/mine/7ph1) | Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Dimos, N, Leppkes, J, Koksch, B, Loll, B. | Deposit date: | 2021-08-16 | Release date: | 2022-03-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment. J.Phys.Chem.B, 126, 2022
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9PTI
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4Y0Y
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![BU of 4y0y by Molmil](/molmil-images/mine/4y0y) | Trypsin in complex with with BPTI | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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3P95
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![BU of 3p95 by Molmil](/molmil-images/mine/3p95) | |
4Y11
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![BU of 4y11 by Molmil](/molmil-images/mine/4y11) | Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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5XX8
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![BU of 5xx8 by Molmil](/molmil-images/mine/5xx8) | |
3WNY
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![BU of 3wny by Molmil](/molmil-images/mine/3wny) | |
5XX6
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1P2J
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![BU of 1p2j by Molmil](/molmil-images/mine/1p2j) | Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin | Descriptor: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | Authors: | Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O. | Deposit date: | 2003-04-15 | Release date: | 2004-04-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333, 2003
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4Y0Z
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![BU of 4y0z by Molmil](/molmil-images/mine/4y0z) | Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4Y10
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![BU of 4y10 by Molmil](/molmil-images/mine/4y10) | Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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5XX5
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![BU of 5xx5 by Molmil](/molmil-images/mine/5xx5) | A BPTI-[5,55] variant with C14GA38I mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5XX7
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4DG4
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![BU of 4dg4 by Molmil](/molmil-images/mine/4dg4) | Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI) | Descriptor: | CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor, ... | Authors: | Salameh, M.A, Soares, A.S, Radisky, E.S. | Deposit date: | 2012-01-24 | Release date: | 2012-09-12 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors. Protein Sci., 21, 2012
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2R9P
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1QLQ
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![BU of 1qlq by Molmil](/molmil-images/mine/1qlq) | Bovine Pancreatic Trypsin Inhibitor (BPTI) Mutant with Altered Binding Loop Sequence | Descriptor: | PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | Authors: | Czapinska, H, Krzywda, S, Sheldrick, G.M, Otlewski, J, Jaskolski, M. | Deposit date: | 1999-09-10 | Release date: | 1999-10-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | High Resolution Structure of Bovine Pancreatic Trypsin Inhibitor with Altered Binding Loop Sequence J.Mol.Biol., 295, 1999
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3FP7
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![BU of 3fp7 by Molmil](/molmil-images/mine/3fp7) | Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) cleaved at the scissile bond (LYS15-ALA16) determined to the 1.46 A resolution limit | Descriptor: | 1,2-ETHANEDIOL, Anionic trypsin-2, CALCIUM ION, ... | Authors: | Zakharova, E, Horvath, M.P, Goldenberg, D.P. | Deposit date: | 2009-01-04 | Release date: | 2009-02-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Structure of a serine protease poised to resynthesize a peptide bond. Proc.Natl.Acad.Sci.USA, 106, 2009
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