6TJT
 
 | | Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide | | Descriptor: | 1,2-ETHANEDIOL, Neuropilin-2, SULFATE ION, ... | | Authors: | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | | Deposit date: | 2019-11-26 | | Release date: | 2020-12-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | NRP2-b1 domain in a complex with the C-terminal VEGFC peptide
To Be Published
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5DQ0
 | | Structure of human neuropilin-2 b1 domain with novel and unique zinc binding site | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | | Authors: | Tsai, Y.I, Rana, R.R, Zachary, I, Djordjevic, S. | | Deposit date: | 2015-09-14 | | Release date: | 2016-09-28 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of human neuropilin-2 b1 domain with novel and unique zinc binding site
To Be Published
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8IVX
 | | Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment | | Descriptor: | 1,2-ETHANEDIOL, Heavy chain of antibody 14V4 Fab fragment, Light chain of antibody 14V4 Fab fragment, ... | | Authors: | Geng, Y, Zhai, L. | | Deposit date: | 2023-03-29 | | Release date: | 2023-07-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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2QQJ
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5DN2
 | | Human NRP2 b1 domain in complex with the peptide corresponding to the C-terminus of VEGF-A | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, GLYCEROL, Neuropilin-2, ... | | Authors: | Tsai, Y.C.I, Frankel, P, Fotinou, C, Rana, R, Zachary, I, Djordjevic, S. | | Deposit date: | 2015-09-09 | | Release date: | 2016-07-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural studies of neuropilin-2 reveal a zinc ion binding site remote from the vascular endothelial growth factor binding pocket.
Febs J., 283, 2016
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4QDQ
 | | Physical basis for Nrp2 ligand binding | | Descriptor: | GLYCEROL, Neuropilin-2, SULFATE ION | | Authors: | Parker, M.W, Vander Kooi, C.W. | | Deposit date: | 2014-05-14 | | Release date: | 2015-04-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
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2QQO
 | | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Appleton, B.A, Wiesmann, C. | | Deposit date: | 2007-07-26 | | Release date: | 2007-11-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
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4QDR
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4QDS
 | | Physical basis for Nrp2 ligand binding | | Descriptor: | ACETATE ION, GLYCEROL, Neuropilin-2 | | Authors: | Parker, M.W, Vander Kooi, C.W. | | Deposit date: | 2014-05-14 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
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6GH8
 | | Crystal structure of GP1 domain of Lujo virus in complex with the first CUB domain of neuropilin-2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glycoprotein, ... | | Authors: | Cohen-Dvashi, H, Kilimnik, I, Diskin, R. | | Deposit date: | 2018-05-06 | | Release date: | 2018-07-25 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural basis for receptor recognition by Lujo virus.
Nat Microbiol, 3, 2018
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6TDB
 | | Neuropilin2-b1 domain in a complex with the C-terminal VEGFB167 peptide | | Descriptor: | 1,2-ETHANEDIOL, ACETYL GROUP, C-terminal VEGFB167 peptide, ... | | Authors: | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | | Deposit date: | 2019-11-08 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | NRP2-b1 domain in a complex with the C-terminal VEGFB167 peptide
To Be Published
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2QQK
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7T4S
 | | CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein H, ... | | Authors: | Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C. | | Deposit date: | 2021-12-10 | | Release date: | 2022-03-23 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
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2QQL
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8IVW
 | | Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment | | Descriptor: | Heavy chian of antibody 10V8 Fab fragment, Light chain of antibody 10V8 Fab fragment, Neuropilin-2 | | Authors: | Geng, Y, Zhai, L. | | Deposit date: | 2023-03-29 | | Release date: | 2023-07-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.205 Å) | | Cite: | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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7M22
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