8IVW

Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment

This is a non-PDB format compatible entry.

Summary for 8IVW

• Entry DOI: 10.2210/pdb8ivw/pdb
• Descriptor: Neuropilin-2, Heavy chian of antibody 10V8 Fab fragment, Light chain of antibody 10V8 Fab fragment (3 entities in total)
• Functional Keywords: complex, antibody, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 456401.96

Authors

Geng, Y.,Zhai, L. (deposition date: 2023-03-29, release date: 2023-07-12, Last modification date: 2023-08-23)

• Primary citation: Xu, Z.,Goel, H.L.,Burkart, C.,Burman, L.,Chong, Y.E.,Barber, A.G.,Geng, Y.,Zhai, L.,Wang, M.,Kumar, A.,Menefee, A.,Polizzi, C.,Eide, L.,Rauch, K.,Rahman, J.,Hamel, K.,Fogassy, Z.,Klopp-Savino, S.,Paz, S.,Zhang, M.,Cubitt, A.,Nangle, L.A.,Mercurio, A.M.; Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.; Sci Transl Med, 15:eadf1128-eadf1128, 2023; PubMed: 37134152; DOI: 10.1126/scitranslmed.adf1128

Experimental method

X-RAY DIFFRACTION (3.205 Å)