8IVW
Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment
This is a non-PDB format compatible entry.
Summary for 8IVW
Entry DOI | 10.2210/pdb8ivw/pdb |
Descriptor | Neuropilin-2, Heavy chian of antibody 10V8 Fab fragment, Light chain of antibody 10V8 Fab fragment (3 entities in total) |
Functional Keywords | complex, antibody, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 456401.96 |
Authors | |
Primary citation | Xu, Z.,Goel, H.L.,Burkart, C.,Burman, L.,Chong, Y.E.,Barber, A.G.,Geng, Y.,Zhai, L.,Wang, M.,Kumar, A.,Menefee, A.,Polizzi, C.,Eide, L.,Rauch, K.,Rahman, J.,Hamel, K.,Fogassy, Z.,Klopp-Savino, S.,Paz, S.,Zhang, M.,Cubitt, A.,Nangle, L.A.,Mercurio, A.M. Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Sci Transl Med, 15:eadf1128-eadf1128, 2023 Cited by PubMed: 37134152DOI: 10.1126/scitranslmed.adf1128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.205 Å) |
Structure validation
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