1PQ1
| Crystal structure of Bcl-xl/Bim | Descriptor: | Apoptosis regulator Bcl-X, BCL2-like protein 11 | Authors: | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | Deposit date: | 2003-06-17 | Release date: | 2003-09-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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2K7W
| BAX Activation is Initiated at a Novel Interaction Site | Descriptor: | Apoptosis regulator BAX, Bcl-2-like protein 11 | Authors: | Gavathiotis, E, Suzuki, M, Davis, M.L, Pitter, K, Bird, G.H, Katz, S.G, Tu, H.C, Kim, H, Cheng, E.H, Tjandra, N, Walensky, L.D. | Deposit date: | 2008-08-27 | Release date: | 2008-10-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | BAX activation is initiated at a novel interaction site. Nature, 455, 2008
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2NL9
| Crystal structure of the Mcl-1:Bim BH3 complex | Descriptor: | Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ... | Authors: | Czabotar, P.E, Colman, P.M. | Deposit date: | 2006-10-19 | Release date: | 2007-03-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA, 104, 2007
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2V6Q
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2VM6
| Human Bcl2-A1 in complex with Bim-BH3 peptide | Descriptor: | BCL-2-LIKE PROTEIN 11, BCL-2-RELATED PROTEIN A1, SULFATE ION | Authors: | Herman, M.D, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-23 | Release date: | 2008-02-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim. FEBS Lett., 582, 2008
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2WH6
| Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain | Descriptor: | BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ... | Authors: | Kvansakul, M, Huang, D.C.S, Colman, P.M. | Deposit date: | 2009-05-01 | Release date: | 2010-05-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. PLoS Pathog., 6, 2010
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2YQ6
| Structure of Bcl-xL bound to BimSAHB | Descriptor: | BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL | Authors: | Smith, B.J, Czabotar, P.E. | Deposit date: | 2012-11-06 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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2YQ7
| Structure of Bcl-xL bound to BimLOCK | Descriptor: | BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL | Authors: | Smith, B.J, Czabotar, P.E. | Deposit date: | 2012-11-06 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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3D7V
| Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand | Descriptor: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | Authors: | Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D. | Deposit date: | 2008-05-22 | Release date: | 2008-06-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J.Cell Biol., 180, 2008
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3FDL
| Bim BH3 peptide in complex with Bcl-xL | Descriptor: | Apoptosis regulator Bcl-X, Bcl-2-like protein 11 | Authors: | Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M. | Deposit date: | 2008-11-26 | Release date: | 2009-03-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L) Angew.Chem.Int.Ed.Engl., 48, 2009
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3IO8
| BimL12F in complex with Bcl-xL | Descriptor: | Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION | Authors: | Colman, P.M, Lee, E.F, Fairlie, W.D, Smith, B.J, Czabotar, P.E, Yang, H, Sleebs, B.E, Lessene, G. | Deposit date: | 2009-08-14 | Release date: | 2009-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J.Biol.Chem., 284, 2009
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3IO9
| BimL12Y in complex with Mcl-1 | Descriptor: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | Authors: | Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D. | Deposit date: | 2009-08-14 | Release date: | 2009-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J.Biol.Chem., 284, 2009
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3KJ0
| Mcl-1 in complex with Bim BH3 mutant I2dY | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ1
| Mcl-1 in complex with Bim BH3 mutant I2dA | Descriptor: | ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ2
| Mcl-1 in complex with Bim BH3 mutant F4aE | Descriptor: | ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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4A1U
| Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL | Descriptor: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ... | Authors: | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | Deposit date: | 2011-09-20 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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4A1W
| Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL | Descriptor: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1 | Authors: | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | Deposit date: | 2011-09-20 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.497 Å) | Cite: | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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4B4S
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4D2M
| Vaccinia Virus F1L bound to Bim BH3 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, BCL-2-LIKE PROTEIN 11, CHLORIDE ION, ... | Authors: | Kvansakul, M, Colman, P.M. | Deposit date: | 2014-05-12 | Release date: | 2014-06-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L. J.Virol., 88, 2014
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4QVF
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4UF3
| Deerpox virus DPV022 in complex with Bim BH3 | Descriptor: | Antiapoptotic membrane protein, Bcl-2-like protein 11 | Authors: | Burton, D.R, Kvansakul, M. | Deposit date: | 2014-12-23 | Release date: | 2015-08-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis of Deerpox Virus-Mediated Inhibition of Apoptosis. Acta Crystallogr.,Sect.D, 71, 2015
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4YJ4
| Crystal structure of Bcl-xL in complex with the BIM BH3 domain containing Ile155-to-Arg and Glu158-to-phosphoserine mutations | Descriptor: | ACETATE ION, Bcl-2-like protein 1, BIM BH3 domain, ... | Authors: | Ku, B, Ha, N.-C, Oh, B.-H. | Deposit date: | 2015-03-03 | Release date: | 2015-07-29 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain. Cell Death Dis, 6, 2015
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4ZIE
| Crystal Structure of core/latch dimer of Bax in complex with BimBH3 | Descriptor: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2-like protein 11 | Authors: | Krishna Kumar, K, Robin, A.Y, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | Deposit date: | 2015-04-28 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. Cell Death Dis, 6, 2015
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4ZIF
| Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | Descriptor: | Apoptosis regulator BAX, Bcl-2-like protein 11 | Authors: | Robin, A.Y, Krishna Kumar, K, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | Deposit date: | 2015-04-28 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. Cell Death Dis, 6, 2015
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4ZIH
| Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | Descriptor: | Apoptosis regulator BAX, Bcl-2-like protein 11 | Authors: | Robin, A.Y, Krishna Kumar, K, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | Deposit date: | 2015-04-28 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. Cell Death Dis, 6, 2015
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