4QVF
Crystal structure of Bcl-xL in complex with BIM BH3 domain
Summary for 4QVF
| Entry DOI | 10.2210/pdb4qvf/pdb |
| Related | 1MAZ 4QVE |
| Descriptor | Bcl-2-like protein 1, Peptide from Bcl-2-like protein 11 (3 entities in total) |
| Functional Keywords | protein-peptide complex, bcl-2 like, heterodimer, apoptosis, anti-apoptotic, bh3 binding, bim bh3 |
| Biological source | Homo sapiens (human) More |
| Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521 |
| Total number of polymer chains | 2 |
| Total formula weight | 22587.91 |
| Authors | Sreekanth, R.,Yoon, H.S. (deposition date: 2014-07-15, release date: 2015-06-10, Last modification date: 2023-11-08) |
| Primary citation | Rajan, S.,Choi, M.,Baek, K.,Yoon, H.S. Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis. Proteins, 83:1262-1272, 2015 Cited by PubMed: 25907960DOI: 10.1002/prot.24816 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.531 Å) |
Structure validation
Download full validation report
