7MGM
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![BU of 7mgm by Molmil](/molmil-images/mine/7mgm) | Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lahiri, I, Reimer, J.M, Leschziner, A.E. | Deposit date: | 2021-04-12 | Release date: | 2022-01-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for cytoplasmic dynein-1 regulation by Lis1. Elife, 11, 2022
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4W8F
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![BU of 4w8f by Molmil](/molmil-images/mine/4w8f) | Crystal structure of the dynein motor domain in the AMPPNP-bound state | Descriptor: | Dynein heavy chain lysozyme chimera, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Cheng, H.-C, Bhabha, G, Zhang, N, Vale, R.D. | Deposit date: | 2014-08-24 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.541 Å) | Cite: | Allosteric communication in the Dynein motor domain. Cell, 159, 2014
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4RH7
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![BU of 4rh7 by Molmil](/molmil-images/mine/4rh7) | Crystal structure of human cytoplasmic dynein 2 motor domain in complex with ADP.Vi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ... | Authors: | Schmidt, H, Zalyte, R, Urnavicius, L, Carter, A.P. | Deposit date: | 2014-10-01 | Release date: | 2014-12-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Structure of human cytoplasmic dynein-2 primed for its power stroke. Nature, 518, 2015
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5NUG
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![BU of 5nug by Molmil](/molmil-images/mine/5nug) | Motor domains from human cytoplasmic dynein-1 in the phi-particle conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Zhang, K, Foster, H.E, Carter, A.P. | Deposit date: | 2017-04-30 | Release date: | 2017-06-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Cell, 169, 2017
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3QMZ
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![BU of 3qmz by Molmil](/molmil-images/mine/3qmz) | Crystal structure of the cytoplasmic dynein heavy chain motor domain | Descriptor: | Cytoplasmic dynein heavy chain, Glutathione-S-transferase | Authors: | Cho, C, Carter, A.P, Jin, L, Vale, R.D. | Deposit date: | 2011-02-07 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Crystal structure of the dynein motor domain. Science, 331, 2011
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8BWY
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![BU of 8bwy by Molmil](/molmil-images/mine/8bwy) | In situ outer dynein arm from Chlamydomonas reinhardtii in a pre-power stroke state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Calmodulin, ... | Authors: | Zimmermann, N.E.L, Noga, A, Obbineni, J.M, Ishikawa, T. | Deposit date: | 2022-12-07 | Release date: | 2023-05-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (38 Å) | Cite: | ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography. Embo J., 42, 2023
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8BX8
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![BU of 8bx8 by Molmil](/molmil-images/mine/8bx8) | In situ outer dynein arm from Chlamydomonas reinhardtii in the post-power stroke state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Zimmermann, N.E.L, Noga, A, Obbineni, J.M, Ishikawa, T. | Deposit date: | 2022-12-08 | Release date: | 2023-05-10 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (30.299999 Å) | Cite: | ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography. Embo J., 42, 2023
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6F3A
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![BU of 6f3a by Molmil](/molmil-images/mine/6f3a) | Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | Authors: | Urnavicius, L, Lau, C.K, Elshenawy, M.M, Morales-Rios, E, Motz, C, Yildiz, A, Carter, A.P. | Deposit date: | 2017-11-28 | Release date: | 2018-01-17 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Cryo-EM shows how dynactin recruits two dyneins for faster movement. Nature, 554, 2018
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6F38
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![BU of 6f38 by Molmil](/molmil-images/mine/6f38) | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | Authors: | Lau, C.K, Urnavicius, L, Elshenawy, M.M, Morales-Rios, E, Motz, C, Yildiz, A, Carter, A.P. | Deposit date: | 2017-11-28 | Release date: | 2018-01-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Cryo-EM shows how dynactin recruits two dyneins for faster movement. Nature, 554, 2018
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5VH9
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![BU of 5vh9 by Molmil](/molmil-images/mine/5vh9) | Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP | Descriptor: | Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 | Authors: | Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2017-04-12 | Release date: | 2017-09-06 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
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5VLJ
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![BU of 5vlj by Molmil](/molmil-images/mine/5vlj) | Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4 | Descriptor: | Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 | Authors: | Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2017-04-25 | Release date: | 2017-09-06 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (10.5 Å) | Cite: | Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
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6RLA
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![BU of 6rla by Molmil](/molmil-images/mine/6rla) | Structure of the dynein-2 complex; motor domains | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-05-01 | Release date: | 2019-08-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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6SC2
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![BU of 6sc2 by Molmil](/molmil-images/mine/6sc2) | Structure of the dynein-2 complex; IFT-train bound model | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 2 light intermediate chain 1, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-07-23 | Release date: | 2019-09-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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6ZYX
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![BU of 6zyx by Molmil](/molmil-images/mine/6zyx) | Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila | Descriptor: | Dynein heavy chain, outer arm protein, Dynein intermediate chain 2, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-01-20 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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6ZYY
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![BU of 6zyy by Molmil](/molmil-images/mine/6zyy) | Outer Dynein Arm-Shulin complex - Dyh3 motor region (Tetrahymena thermophila) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Begum, F, Boulanger, J, Howe, J.D, Chen, Z.A, Rappsilber, J, Skehel, M, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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6ZYW
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![BU of 6zyw by Molmil](/molmil-images/mine/6zyw) | Outer Dynein Arm-Shulin complex - overall structure (Tetrahymena thermophila) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-01-20 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (8.78 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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6RLB
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![BU of 6rlb by Molmil](/molmil-images/mine/6rlb) | Structure of the dynein-2 complex; tail domain | Descriptor: | Cytoplasmic dynein 2 light intermediate chain 1, Dynein light chain 1, cytoplasmic, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-05-01 | Release date: | 2019-08-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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8FDT
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![BU of 8fdt by Molmil](/molmil-images/mine/8fdt) | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ... | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-04 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8FD6
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![BU of 8fd6 by Molmil](/molmil-images/mine/8fd6) | Engineered human dynein motor domain in the microtubule-unbound state in the buffer containing ATP-Vi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ... | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-02 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8FDU
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![BU of 8fdu by Molmil](/molmil-images/mine/8fdu) | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-04 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8FCY
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![BU of 8fcy by Molmil](/molmil-images/mine/8fcy) | Engineered human dynein motor domain in microtubule-bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-01 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8DYV
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![BU of 8dyv by Molmil](/molmil-images/mine/8dyv) | Structure of human cytoplasmic dynein-1 bound to one Lis1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2022-08-05 | Release date: | 2023-02-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife, 12, 2023
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8DYU
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![BU of 8dyu by Molmil](/molmil-images/mine/8dyu) | Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2022-08-05 | Release date: | 2023-02-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife, 12, 2023
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8DZZ
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![BU of 8dzz by Molmil](/molmil-images/mine/8dzz) | Cryo-EM structure of chi dynein bound to Lis1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Reimer, J.M, Lahiri, I, Leschziner, A.E. | Deposit date: | 2022-08-08 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat.Struct.Mol.Biol., 30, 2023
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8E00
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![BU of 8e00 by Molmil](/molmil-images/mine/8e00) | Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Reimer, J.M, Lahiri, I, Leschziner, A.E. | Deposit date: | 2022-08-08 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat.Struct.Mol.Biol., 30, 2023
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