8FCY

Engineered human dynein motor domain in microtubule-bound state

Summary for 8FCY

• Entry DOI: 10.2210/pdb8fcy/pdb
• EMDB information: 28999
• Descriptor: Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
• Functional Keywords: dynein, motor domain, microtubule-bound, motor protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 359720.41

Authors

Ton, W.,Wang, Y.,Chai, P. (deposition date: 2022-12-01, release date: 2023-06-21, Last modification date: 2023-11-15)

• Primary citation: Ton, W.D.,Wang, Y.,Chai, P.,Beauchamp-Perez, C.,Flint, N.T.,Lammers, L.G.,Xiong, H.,Zhang, K.,Markus, S.M.; Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.; Nat.Struct.Mol.Biol., 30:1365-1379, 2023; PubMed: 37322240; DOI: 10.1038/s41594-023-01010-x

Experimental method

ELECTRON MICROSCOPY (3.4 Å)