4W8I
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![BU of 4w8i by Molmil](/molmil-images/mine/4w8i) | Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase | Descriptor: | Probable sphingosine-1-phosphate lyase | Authors: | Stogios, P.J, Daniels, C, Skarina, T, Cuff, M, Di Leo, R, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-08-24 | Release date: | 2014-11-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy. Proc.Natl.Acad.Sci.USA, 113, 2016
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8CMX
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![BU of 8cmx by Molmil](/molmil-images/mine/8cmx) | |
6M4Y
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![BU of 6m4y by Molmil](/molmil-images/mine/6m4y) | |
3VP6
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![BU of 3vp6 by Molmil](/molmil-images/mine/3vp6) | Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation | Descriptor: | 4-oxo-4H-pyran-2,6-dicarboxylic acid, GLYCEROL, Glutamate decarboxylase 1 | Authors: | Langendorf, C.G, Tuck, K.L, Key, T.L.G, Rosado, C.J, Wong, A.S.M, Fenalti, G, Buckle, A.M, Law, R.H.P, Whisstock, J.C. | Deposit date: | 2012-02-27 | Release date: | 2013-01-16 | Last modified: | 2013-08-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates Biosci.Rep., 33, 2013
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5K1R
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![BU of 5k1r by Molmil](/molmil-images/mine/5k1r) | |
2JIS
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![BU of 2jis by Molmil](/molmil-images/mine/2jis) | Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP. | Descriptor: | CYSTEINE SULFINIC ACID DECARBOXYLASE, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE | Authors: | Collins, R, Moche, M, Arrowsmith, C, Berglund, H, Busam, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-30 | Release date: | 2007-08-28 | Last modified: | 2015-04-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Crystal Structure of Human Cysteine Sulfinic Acid Decarboxylase (Csad) To be Published
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4E1O
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![BU of 4e1o by Molmil](/molmil-images/mine/4e1o) | Human histidine decarboxylase complex with Histidine methyl ester (HME) | Descriptor: | HISTIDINE-METHYL-ESTER, Histidine decarboxylase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Komori, H, Nitta, Y, Ueno, H, Higuchi, Y. | Deposit date: | 2012-03-06 | Release date: | 2012-07-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase J.Biol.Chem., 287, 2012
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8AYF
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![BU of 8ayf by Molmil](/molmil-images/mine/8ayf) | Crystal structure of human Sphingosine-1-phosphate lyase 1 | Descriptor: | ACETATE ION, GLYCEROL, Sphingosine-1-phosphate lyase 1 | Authors: | Giardina, G, Catalano, F, Pampalone, G, Cellini, B. | Deposit date: | 2022-09-02 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study. Sci Rep, 13, 2023
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5O5C
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![BU of 5o5c by Molmil](/molmil-images/mine/5o5c) | The crystal structure of DfoJ, the desferrioxamine biosynthetic pathway lysine decarboxylase from the fire blight disease pathogen Erwinia amylovora | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Putative decarboxylase involved in desferrioxamine biosynthesis | Authors: | Salomone-Stagni, M, Bartho, J.D, Polsinelli, I, Bellini, D, Walsh, M.A, Demitri, N, Benini, S. | Deposit date: | 2017-06-01 | Release date: | 2018-02-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora. J. Struct. Biol., 202, 2018
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7JZH
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![BU of 7jzh by Molmil](/molmil-images/mine/7jzh) | |
1XEY
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![BU of 1xey by Molmil](/molmil-images/mine/1xey) | Crystal structure of the complex of Escherichia coli GADA with glutarate at 2.05 A resolution | Descriptor: | ACETATE ION, GLUTARIC ACID, Glutamate decarboxylase alpha, ... | Authors: | Dutyshev, D.I, Darii, E.L, Fomenkova, N.P, Pechik, I.V, Polyakov, K.M, Nikonov, S.V, Andreeva, N.S, Sukhareva, B.S. | Deposit date: | 2004-09-13 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of Escherichia coli glutamate decarboxylase (GADalpha) in complex with glutarate at 2.05 angstroms resolution. Acta Crystallogr.,Sect.D, 61, 2005
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4RM1
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![BU of 4rm1 by Molmil](/molmil-images/mine/4rm1) | |
6ZEK
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![BU of 6zek by Molmil](/molmil-images/mine/6zek) | Crystal structure of mouse CSAD | Descriptor: | CHLORIDE ION, COBALT (II) ION, Cysteine sulfinic acid decarboxylase, ... | Authors: | Mahootchi, E, Raasakka, A, Haavik, J, Kursula, P. | Deposit date: | 2020-06-16 | Release date: | 2021-04-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase. J.Struct.Biol., 213, 2021
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4RLG
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![BU of 4rlg by Molmil](/molmil-images/mine/4rlg) | |
1PMM
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![BU of 1pmm by Molmil](/molmil-images/mine/1pmm) | Crystal structure of Escherichia coli GadB (low pH) | Descriptor: | ACETIC ACID, Glutamate decarboxylase beta, PYRIDOXAL-5'-PHOSPHATE | Authors: | Capitani, G, De Biase, D, Aurizi, C, Gut, H, Bossa, F, Grutter, M.G. | Deposit date: | 2003-06-11 | Release date: | 2004-02-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure and functional analysis of escherichia coli glutamate
decarboxylase Embo J., 22, 2003
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7A0A
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![BU of 7a0a by Molmil](/molmil-images/mine/7a0a) | Crystal structure of mouse CSAD in apo form | Descriptor: | Cysteine sulfinic acid decarboxylase, SODIUM ION, SULFATE ION | Authors: | Mahootchi, E, Raasakka, A, Haavik, J, Kursula, P. | Deposit date: | 2020-08-07 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structure of cysteine sulphinic acid decarboxylase reveals structural determinants for substrate specificity of pyridoxal phosphate-dependent decarboxylases To be published
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1JS6
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![BU of 1js6 by Molmil](/molmil-images/mine/1js6) | Crystal Structure of DOPA decarboxylase | Descriptor: | DOPA decarboxylase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Burkhard, P, Dominici, P, Borri-Voltattorni, C, Jansonius, J.N, Malashkevich, V.N. | Deposit date: | 2001-08-16 | Release date: | 2001-10-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase. Nat.Struct.Biol., 8, 2001
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3HBX
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![BU of 3hbx by Molmil](/molmil-images/mine/3hbx) | Crystal structure of GAD1 from Arabidopsis thaliana | Descriptor: | Glutamate decarboxylase 1 | Authors: | Gut, H, Dominici, P, Pilati, S, Gruetter, M.G, Capitani, G. | Deposit date: | 2009-05-05 | Release date: | 2009-07-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.672 Å) | Cite: | A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J.Mol.Biol., 392, 2009
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5EUE
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![BU of 5eue by Molmil](/molmil-images/mine/5eue) | S1P Lyase Bacterial Surrogate bound to N-(2-((4-methoxy-2,5-dimethylbenzyl)amino)-1-phenylethyl)-5-methylisoxazole-3-carboxamide | Descriptor: | PHOSPHATE ION, Putative sphingosine-1-phosphate lyase, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-phenyl-ethyl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M. | Deposit date: | 2015-11-18 | Release date: | 2016-03-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Creation of a S1P Lyase bacterial surrogate for structure-based drug design. Bioorg.Med.Chem.Lett., 26, 2016
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3K40
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![BU of 3k40 by Molmil](/molmil-images/mine/3k40) | Crystal structure of Drosophila 3,4-dihydroxyphenylalanine decarboxylase | Descriptor: | Aromatic-L-amino-acid decarboxylase, GLYCEROL | Authors: | Han, Q, Ding, H, Robinson, H, Christensen, B.M, Li, J. | Deposit date: | 2009-10-05 | Release date: | 2010-02-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase Plos One, 5, 2010
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5EUD
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![BU of 5eud by Molmil](/molmil-images/mine/5eud) | S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide | Descriptor: | PHOSPHATE ION, Putative sphingosine-1-phosphate lyase, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-[4-(3-oxidanylprop-1-ynyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M. | Deposit date: | 2015-11-18 | Release date: | 2016-03-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Creation of a S1P Lyase bacterial surrogate for structure-based drug design. Bioorg.Med.Chem.Lett., 26, 2016
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1JS3
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![BU of 1js3 by Molmil](/molmil-images/mine/1js3) | Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa | Descriptor: | CARBIDOPA, DOPA decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Burkhard, P, Dominici, P, Borri-Voltattorni, C, Jansonius, J.N, Malashkevich, V.N. | Deposit date: | 2001-08-16 | Release date: | 2001-10-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase. Nat.Struct.Biol., 8, 2001
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1PMO
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![BU of 1pmo by Molmil](/molmil-images/mine/1pmo) | Crystal structure of Escherichia coli GadB (neutral pH) | Descriptor: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glutamate decarboxylase beta | Authors: | Capitani, G, De Biase, D, Aurizi, C, Gut, H, Bossa, F, Grutter, M.G. | Deposit date: | 2003-06-11 | Release date: | 2004-02-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure and functional analysis of escherichia coli glutamate
decarboxylase Embo J., 22, 2003
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2DGL
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![BU of 2dgl by Molmil](/molmil-images/mine/2dgl) | Crystal structure of Escherichia coli GadB in complex with bromide | Descriptor: | ACETIC ACID, BROMIDE ION, Glutamate decarboxylase beta, ... | Authors: | Gruetter, M.G, Capitani, G, Gut, H. | Deposit date: | 2006-03-14 | Release date: | 2006-06-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB Embo J., 25, 2006
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2DGM
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![BU of 2dgm by Molmil](/molmil-images/mine/2dgm) | Crystal structure of Escherichia coli GadB in complex with iodide | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | Authors: | Gruetter, M.G, Capitani, G, Gut, H. | Deposit date: | 2006-03-14 | Release date: | 2006-06-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB Embo J., 25, 2006
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