8AYF

Crystal structure of human Sphingosine-1-phosphate lyase 1

Summary for 8AYF

• Entry DOI: 10.2210/pdb8ayf/pdb
• Descriptor: Sphingosine-1-phosphate lyase 1, ACETATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: s1p, lipid, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110298.79

Authors

Giardina, G.,Catalano, F.,Pampalone, G.,Cellini, B. (deposition date: 2022-09-02, release date: 2023-09-13, Last modification date: 2024-01-03)

• Primary citation: Cellini, B.,Pampalone, G.,Camaioni, E.,Pariano, M.,Catalano, F.,Zelante, T.,Dindo, M.,Macchioni, L.,Di Veroli, A.,Galarini, R.,Paoletti, F.,Davidescu, M.,Stincardini, C.,Vascelli, G.,Bellet, M.M.,Saba, J.,Giovagnoli, S.,Giardina, G.,Romani, L.,Costantini, C.; Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.; Sci Rep, 13:22692-22692, 2023; PubMed: 38123809; DOI: 10.1038/s41598-023-50121-4

Experimental method

X-RAY DIFFRACTION (1.84 Å)