8ORA

Human holo aromatic L-amino acid decarboxylase (AADC) external aldimine with L-Dopa methylester

Summary for 8ORA

• Entry DOI: 10.2210/pdb8ora/pdb
• Related: 8OR9
• Descriptor: Dopa decarboxylase (Aromatic L-amino acid decarboxylase), PYRIDOXAL-5'-PHOSPHATE, methyl (2~{R})-2-azanyl-3-[3,4-bis(oxidanyl)phenyl]propanoate, ... (5 entities in total)
• Functional Keywords: dopa decarboxilase, human aromatic amino acid decarboxylase, aadc deficiency, l-dopa, dopamine, pyridoxal phosphate, plp, melevodopa, dopa methylester, dme, catalytic loop, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 54615.78

Authors

Bisello, G.,Perduca, M.,Bertoldi, M. (deposition date: 2023-04-13, release date: 2023-08-30)

• Primary citation: Bisello, G.,Ribeiro, R.P.,Perduca, M.,Belviso, B.D.,Polverino De' Laureto, P.,Giorgetti, A.,Caliandro, R.,Bertoldi, M.; Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency.; Protein Sci., 32:e4732-e4732, 2023; PubMed: 37466248; DOI: 10.1002/pro.4732

Experimental method

X-RAY DIFFRACTION (2.4 Å)