8OR9

Human holo aromatic L-amino acid decarboxylase (AADC) native structure at physiological pH

Summary for 8OR9

Entry DOI	10.2210/pdb8or9/pdb
Descriptor	Dopa decarboxylase (Aromatic L-amino acid decarboxylase), PYRIDOXAL-5'-PHOSPHATE, TETRAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	dopa decarboxilase, human aromatic amino acid decarboxylase, aadc deficiency, l-dopa, dopamine, pyridoxal phosphate, plp, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	54404.56
Authors	Bisello, G.,Perduca, M.,Bertoldi, M. (deposition date: 2023-04-13, release date: 2023-08-30)
Primary citation	Bisello, G.,Ribeiro, R.P.,Perduca, M.,Belviso, B.D.,Polverino De' Laureto, P.,Giorgetti, A.,Caliandro, R.,Bertoldi, M. Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency. Protein Sci., 32:e4732-e4732, 2023 Cited by PubMed: 37466248 DOI: 10.1002/pro.4732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation