8OR9
Human holo aromatic L-amino acid decarboxylase (AADC) native structure at physiological pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001822 | biological_process | kidney development |
| A | 0004058 | molecular_function | aromatic-L-amino-acid decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0010467 | biological_process | gene expression |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0036467 | molecular_function | 5-hydroxy-L-tryptophan decarboxylase activity |
| A | 0036468 | molecular_function | L-dopa decarboxylase activity |
| A | 0042416 | biological_process | dopamine biosynthetic process |
| A | 0042423 | biological_process | catecholamine biosynthetic process |
| A | 0042427 | biological_process | serotonin biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00392 |
| Number of Residues | 22 |
| Details | DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFnFnphKWLlVnFDCsaMWvK |
| Chain | Residue | Details |
| A | SER296-LYS317 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P80041 |
| Chain | Residue | Details |
| A | THR82 | |
| A | HIS192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22143761, ECO:0007744|PDB:3RCH |
| Chain | Residue | Details |
| A | ALA148 | |
| A | SER149 | |
| A | THR246 | |
| A | ASN300 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P80041 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:22143761 |
| Chain | Residue | Details |
| A | LYS303 |
