4W8I

Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase

Summary for 4W8I

• Entry DOI: 10.2210/pdb4w8i/pdb
• Descriptor: Probable sphingosine-1-phosphate lyase (2 entities in total)
• Functional Keywords: effector, structural genomics, psi-biology, midwest center for structural genomics, mcsg, lyase
• Biological source: Legionella pneumophila
• Total number of polymer chains: 2
• Total formula weight: 121674.86

Authors

Stogios, P.J.,Daniels, C.,Skarina, T.,Cuff, M.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2014-08-24, release date: 2014-11-05, Last modification date: 2024-03-13)

• Primary citation: Rolando, M.,Escoll, P.,Nora, T.,Botti, J.,Boitez, V.,Bedia, C.,Daniels, C.,Abraham, G.,Stogios, P.J.,Skarina, T.,Christophe, C.,Dervins-Ravault, D.,Cazalet, C.,Hilbi, H.,Rupasinghe, T.W.,Tull, D.,McConville, M.J.,Ong, S.Y.,Hartland, E.L.,Codogno, P.,Levade, T.,Naderer, T.,Savchenko, A.,Buchrieser, C.; Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.; Proc.Natl.Acad.Sci.USA, 113:1901-1906, 2016; PubMed: 26831115; DOI: 10.1073/pnas.1522067113

Experimental method

X-RAY DIFFRACTION (2.85 Å)